Université de Fribourg

Crystal Structure of Borrelia turicatae protein, BTA121, a differentially regulated gene in the tick-mammalian transmission cycle of relapsing fever spirochetes

Luo, Zhipu ; Kelleher, Alan J. ; Darwiche, Rabih ; Hudspeth, Elissa M. ; Shittu, Oluwatosin K. ; Krishnavajhala, Aparna ; Schneiter, Roger ; Lopez, Job E. ; Asojo, Oluwatoyin A.

In: Scientific Reports, 2017, vol. 7, no. 1, p. 15310

Tick-borne relapsing fever (RF) borreliosis is a neglected disease that is often misdiagnosed. RF species circulating in the United States include Borrelia turicatae, which is transmitted by argasid ticks. Environmental adaptation by RF Borrelia is poorly understood, however our previous studies indicated differential regulation of B. turicatae genes localized on the 150 kb linear...

Université de Fribourg

Crystal structure of MpPR-1i, a SCP/TAPS protein from Moniliophthora perniciosa , the fungus that causes witches’ broom disease of cacao

Baroni, Renata M. ; Luo, Zhipu ; Darwiche, Rabih ; Hudspeth, Elissa M. ; Schneiter, Roger ; Pereira, Gonçalo A. G. ; Mondego, Jorge M. C. ; Asojo, Oluwatoyin A.

In: Scientific Reports, 2017, vol. 7, no. 1, p. 7818

The pathogenic fungi Moniliophthora perniciosa causes Witches’ Broom Disease (WBD) of cacao. The structure of MpPR-1i, a protein expressed by M. perniciosa when it infects cacao, are presented. This is the first reported de novo structure determined by single-wavelength anomalous dispersion phasing upon soaking with selenourea. Each monomer has flexible loop regions linking the core...