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    3 results 1
    Université de Fribourg

    Crystal Structure of Borrelia turicatae protein, BTA121, a differentially regulated gene in the tick-mammalian transmission cycle of relapsing fever spirochetes

    Luo, Zhipu ; Kelleher, Alan J. ; Darwiche, Rabih ; Hudspeth, Elissa M. ; Shittu, Oluwatosin K. ; Krishnavajhala, Aparna ; Schneiter, Roger ; Lopez, Job E. ; Asojo, Oluwatoyin A.

    In: Scientific Reports, 2017, vol. 7, no. 1, p. 15310

    Tick-borne relapsing fever (RF) borreliosis is a neglected disease that is often misdiagnosed. RF species circulating in the United States include Borrelia turicatae, which is transmitted by argasid ticks. Environmental adaptation by RF Borrelia is poorly understood, however our previous studies indicated differential regulation of B. turicatae genes localized on the 150 kb linear...

    Université de Fribourg

    Crystal structure of MpPR-1i, a SCP/TAPS protein from Moniliophthora perniciosa , the fungus that causes witches’ broom disease of cacao

    Baroni, Renata M. ; Luo, Zhipu ; Darwiche, Rabih ; Hudspeth, Elissa M. ; Schneiter, Roger ; Pereira, Gonçalo A. G. ; Mondego, Jorge M. C. ; Asojo, Oluwatoyin A.

    In: Scientific Reports, 2017, vol. 7, no. 1, p. 7818

    The pathogenic fungi Moniliophthora perniciosa causes Witches’ Broom Disease (WBD) of cacao. The structure of MpPR-1i, a protein expressed by M. perniciosa when it infects cacao, are presented. This is the first reported de novo structure determined by single-wavelength anomalous dispersion phasing upon soaking with selenourea. Each monomer has flexible loop regions linking the core...

    Université de Fribourg

    Structural and functional characterization of the CAP domain of pathogen-related yeast 1 (Pry1) protein

    Darwiche, Rabih ; Kelleher, Alan ; Hudspeth, Elissa M. ; Schneiter, Roger ; Asojo, Oluwatoyin A.

    In: Scientific Reports, 2016, vol. 6, p. 28838

    The production, crystal structure, and functional characterization of the C-terminal cysteine-rich secretory protein/antigen 5/pathogenesis related-1 (CAP) domain of pathogen-related yeast protein-1 (Pry1) from Saccharomyces cerevisiae is presented. The CAP domain of Pry1 (Pry1CAP) is functional in vivo as its expression restores cholesterol export to yeast mutants lacking endogenous Pry1 and...

    3 results 1