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Valproate induces the unfolded protein response by increasing ceramide levels

Jadhav, Shyamalagauri ; Russo, Sarah ; Cottier, Stéphanie ; Schneiter, Roger ; Cowart, Ashley ; Greenberg, Miriam L.

In: Journal of Biological Chemistry, 2016, vol. 291, no. 42, p. 22253–22261

Bipolar disorder (BD), which is characterized by depression and mania, affects 1–2% of the world population. Current treatments are effective in only 40–60% of cases and cause severe side effects. Valproate (VPA) is one of the most widely used drugs for the treatment of BD, but the therapeutic mechanism of action of this drug is not understood. This knowledge gap has hampered the...