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Occurrence of the plasmid-borne mcr-1 colistin resistance gene in extended-spectrum-β-lactamase-producing Enterobacteriaceae in river water and imported vegetable samples in Switzerland

Zurfuh, Katrin ; Poirel, Laurent ; Nordmann, Patrice ; Nüesch-Inderbinen, Magdalena ; Hächler, Herbert ; Stephan, Roger

In: Antimicrobial Agents and Chemotherapy, 2016, vol. 60, no. 4, p. 2594–2595

Emergence of Escherichia coli producing OXA-48 β-lactamase in the community in Switzerland

Zurfluh, Katrin ; Nüesch-Inderbinen, Magdalena T ; Poirel, Laurent ; Nordmann, Patrice ; Hächler, Herbert ; Stephan, Roger

In: Antimicrobial Resistance and Infection Control, 2016, vol. 4, p. 9

The emergence and worldwide spread of carbapenemase-producing Enterobacteriaceae is of great concern to public health services. The aim of this study was to investigate the occurrence of carbapenemase-producing Enterobacteriaceae in the community in Switzerland.Findings: One thousand and eighty-six stool samples of healthy humans (staff members of a food-processing company which were screened...

Features of the mcr-1 cassette related to colistin resistance

Zurfluh, Katrin ; Kieffer, Nicolas ; Poirel, Laurent ; Nordmann, Patrice ; Stephan, Roger

In: Antimicrobial Agents and Chemotherapy, 2016, vol. 60, no. 10, p. 6438–6439

Full genome sequence of pT3, a multiresistant plasmid carrying the mcr-3.5 colistin resistance gene, recovered from an extended-spectrum-β-lactamase-producing Escherichia coli isolate from crickets sold as food

Zurfluh, Katrin ; Stevens, Marc J. A. ; Bucher, Melissa ; Poirel, Laurent ; Nordmann, Patrice ; Stephan, Roger

In: Microbiology Resource Announcements, 2019/8/29/e00647-19, /mra/8/29/MRA.00647-19.atom

Here, we sequenced multidrug resistance plasmid pT3, which encodes mcr-3.5 and other resistance genes. The cooccurrence of mcr genes and other resistance genes on a single plasmid is of concern.

Key features of mcr-1-bearing plasmids from Escherichia coli isolated from humans and food

Zurfluh, Katrin ; Nüesch-Inderbinen, Magdalena ; Klumpp, Jochen ; Poirel, Laurent ; Nordmann, Patrice ; Stephan, Roger

In: Antimicrobial Resistance & Infection Control, 2017, vol. 6, p. 91

Mcr-1-harboring Enterobacteriaceae are reported worldwide since their first discovery in 2015. However, a limited number of studies are available that compared full-length plasmid sequences of human and animal origins.

Screening for fecal carriage of MCR-producing Enterobacteriaceae in healthy humans and primary care patients

Zurfluh, Katrin ; Stephan, Roger ; Widmer, Andreas ; Poirel, Laurent ; Nordmann, Patrice ; Nüesch, Hans-Jakob ; Hächler, Herbert ; Nüesch-Inderbinen, Magdalena

In: Antimicrobial Resistance & Infection Control, 2017, vol. 6, p. 28

The objective of this study was to test the efficacy of an inhibitor of the New Delhi metallo-β- lactamase (NDM-1). Inhibiting expression of this type of antibiotic-resistance gene has the potential to restore antibiotic susceptibility in all bacteria carrying the gene.Methods: We have constructed a peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) that selectively inhibits...

Occurrence and features of chromosomally encoded carbapenemases in Gram-negative bacteria in farm animals sampled at slaughterhouse level

Zurfluh, Katrin ; Hindermann, D. ; Nüesch-Inderbinen, Magdalena ; Poirel, Laurent ; Nordmann, Patrice ; Stephan, Roger

In: Archives Suisses de Médecine Vétérinaire, 2016, vol. 158, no. 6, p. 457-460

First detection of Klebsiella variicola producing OXA-181 carbapenemase in fresh vegetable imported from Asia to Switzerland

Zurfluh, K. ; Poirel, Laurent ; Nordmann, Patrice ; Klumpp, J. ; Stephan, R.

In: Antimicrobial Resistance and Infection Control, 2015, vol. 4, p. 38

Background: The emergence and worldwide spread of carbapenemase-producing Enterobacteriaceae is of great concern to public health services. The aim of this study was to investigate the occurrence of carbapenemase-producing Enterobacteriaceae in fresh vegetables and spices imported from Asia to Switzerland.Findings: Twenty-two different fresh vegetable samples were purchased in March 2015 from...

The type I-E CRISPR-Cas system influences the acquisition of bla KPC-IncF plasmid in Klebsiella pneumonia

Zhou, Ying ; Tang, Yu ; Fu, Pan ; Tian, Dongxing ; Yu, Lianhua ; Huang, Yunkun ; Li, Gang ; Li, Meng ; Wang, Yong ; Yang, Zehua ; Xu, Xiaogang ; Yin, Zhe ; Zhou, Dongsheng ; Poirel, Laurent ; Jiang, Xiaofei

In: Emerging Microbes & Infections, 2020, vol. 9, no. 1, p. 1011–1022

Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) have disseminated worldwide and emerged as major threats to public health. Of epidemiological significance, the international pandemic of KPC-KP is primarily associated with CG258 isolates and bla KPC-IncF plasmids. CRISPR-Cas system is an adaptive immune system that can hinder gene expansion driven by horizontal gene ...

High-risk KPC-producing Klebsiella pneumoniae lack type I R-M systems

Zhou, Ying ; Tian, Dongxing ; Tang, Yu ; Yu, Lianhua ; Huang, Yunkun ; Li, Gang ; Li, Meng ; Wang, Yong ; Yang, Zehua ; Poirel, Laurent ; Jiang, Xiaofei

In: International Journal of Antimicrobial Agents, 2020, vol. 56, no. 2, p. 106050

Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) have disseminated worldwide and are a major threat to public health. The multidrug- resistant (MDR)-phenotype of KPC-KP are commonly associated with the presence of high molecular weight blaKPC plasmids. Restriction-modification (R-M) systems provide bacteria with innate defense against plasmids or other infectious gene...