Université de Fribourg

Prevalence of faecal carriage of colistin-resistant Gram-negative rods in a university hospital in western France, 2016

Saly, Marion ; Jayol, Aurélie ; Poirel, Laurent ; Megraud, Francis ; Nordmann, Patrice ; Dubois, Véronique

In: Journal of Medical Microbiology, 2017, vol. 66, no. 6, p. 842–843

Plasmid-mediated and chromosomally-encoded colistin resistance is increasingly being reported worldwide. We aimed to determine the prevalence of faecal carriage of colistin-resistant Gram-negative rod isolates in a university hospital in western France. From February to May 2016, rectal swabs from 653 patients hospitalized in various clinical settings were recovered and subsequently screened...

Université de Fribourg

The mgrB gene as a key target for acquired resistance to colistin in Klebsiella pneumoniae

Poirel, Laurent ; Jayol, Aurélie ; Bontron, Séverine ; Villegas, Maria-Virginia ; Ozdamar, Melda ; Türkoglu, Salih ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2015, vol. 70, no. 1, p. 75-80

Objectives Alterations in the PhoPQ two-component regulatory system may be associated with colistin resistance in Klebsiella pneumoniae. MgrB is a small transmembrane protein produced upon activation of the PhoPQ signalling system, and acts as a negative regulator on this system. We investigated the role of the MgrB protein as a source of colistin resistance in a series of K. pneumoniae.Methods...