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Université de Fribourg

Taylor dispersion of inorganic nanoparticles and comparison to dynamic light scattering and transmission electron microscopy

A.Urban, Dominic ; M.Milosevic, Ana ; Bossert, David ; Crippa, Federica ; L.Moore, Thomas ; Geers, Christoph ; Balog, Sandor ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Colloid and Interface Science Communications, 2018, vol. 22, p. 29–33

Taylor dispersion analysis (TDA) is an analytical method that has so far mainly been utilized to determine the diffusion coefficient of small molecules, and proteins. Due to increasing interest in nanoscience, some research has been done on the applicability of TDA towards characterizing nanoparticles. This work aims to expand this knowledge and give insight into the range for which TDA can...

Université de Fribourg

Translocation of gold nanoparticles across the lung epithelial tissue barrier: Combining in vitro and in silico methods to substitute in vivo experiments

Bachler, Gerald ; Losert, Sabrina ; Umehara, Yuki ; Goetz, Natalie von ; Rodriguez-Lorenzo, Laura ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Hungerbuehler, Konrad

In: Particle and Fibre Toxicology, 2015, vol. 12, no. 1, p. 18

The lung epithelial tissue barrier represents the main portal for entry of inhaled nanoparticles (NPs) into the systemic circulation. Thus great efforts are currently being made to determine adverse health effects associated with inhalation of NPs. However, to date very little is known about factors that determine the pulmonary translocation of NPs and their subsequent distribution to secondary...

Université de Fribourg

Dynamic depolarized light scattering of small round plasmonic nanoparticles: When imperfection is only perfect

Balog, Sandor ; Adolphe Merkle Institute, University of Fribourg, Switzerland ; Rodriguez-Lorenzo, Laura ; Monnier, Christophe A. ; Michen, Benjamin ; Obiols-Rabasa, Marc ; Casal-Dujat, Lucia ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke ; Schurtenberger, and Peter

In: The Journal of Physical Chemistry C, 2014, vol. 118, no. 31, p. 17968–17974

Although small round gold nanoparticles (Au NPs) possess only a small degree of shape anisotropy, they support localized surface plasmon resonances and exhibit intrinsic optical anisotropy. These inherent features promote depolarized light scattering, whose temporal fluctuations carry information about rotational Brownian dynamics, and thus can be used to describe the size distribution of round...

Université de Fribourg

Characterizing nanoparticles in complex biological media and physiological fluids with depolarized dynamic light scattering

Balog, Sandor ; Rodriguez-Lorenzo, Laura ; Monnier, Christophe A. ; Obiols-Rabas, Marc ; Rothen-Rutishauser, Barbara ; Schurtenberger, Peter ; Petri-Fink, Alke

In: Nanoscale, 2015, p. -

Light scattering is one of the few techniques available to adequately characterize suspended nanoparticles (NPs) in real time and in situ. However, when it comes to NPs in multicomponent and optically complex aqueous matrices – such as biological media and physiological fluids – light scattering suffers from lack of selectivity, as distinguishing the relevant optical signals from the...

Université de Fribourg

Biological response of an in vitro human 3D lung cell model exposed to brake wear debris varies based on brake pad formulation

Barosova, Hana ; Chortarea, Savvina ; Peikertova, Pavlina ; J. D. Clift, Martin ; Petri-Fink, Alke ; Kukutschova, Jana ; Rothen-Rutishauser, Barbara

In: Archives of Toxicology, 2018, vol. 92, no. 7, p. 2339–2351

Wear particles from automotive friction brake pads of various sizes, morphology, and chemical composition are significant contributors towards particulate matter. Knowledge concerning the potential adverse effects following inhalation exposure to brake wear debris is limited. Our aim was, therefore, to generate brake wear particles released from commercial low-metallic and non-asbestos organic...

Université de Fribourg

Mimicking the chemistry of natural eumelanin synthesis: the ke sequence in polypeptides and in proteins allows for a specific control of nanosized functional polydopamine formation

Bergtold, Camille ; Hauser, Daniel ; Alain Chaumont ; El Yakhlifi, Salima ; Mateescu, Mihaela ; Meyer, Florent ; Metz-Boutigue, Marie-Hélène ; Benoît Frisch ; Schaaf, Pierre ; Ihiawakrim, Dris ; Ersen, Ovidiu ; Monnier, Christophe A. ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Ball, Vincent

In: Biomacromolecules, 2018, vol. 19, no. 9, p. 3693–3704

The oxidation of dopamine and of other catecholamines leads to the formation of conformal films on the surface of all known materials and to the formation of a precipitate in solution. In some cases, it has been shown that the addition of additives in the dopamine solution, like certain surfactants or polymers, polyelectrolytes, and certain proteins, allows to get polydopamine nanoparticles...

Université de Fribourg

Assessment of lung cell toxicity of various gasoline engine exhausts using a versatile in vitro exposure system

Bisig, Christoph ; Comte, Pierre ; Güdel, Martin ; Czerwinski, Jan ; Mayer, Andreas ; Müller, Loretta ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Environmental Pollution, 2018, vol. 235, p. 263–271

Adverse effect studies of gasoline exhaust are scarce, even though gasoline direct injection (GDI) vehicles can emit a high number of particles. The aim of this study was to conduct an in vitro hazard assessment of different GDI exhausts using two different cell culture models mimicking the human airway. In addition to gasoline particle filters (GPF), the effects of two lubrication oils with...

Université de Fribourg

Biological effects in lung cells In vitro of exhaust aerosols from a gasoline passenger car with and without particle filter

Bisig, Christoph ; Steiner, Sandro ; Comte, Pierre ; Czerwinski, Jan ; Mayer, Andreas ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Emission Control Science and Technology, 2015, vol. 1, no. 3, p. 237–246

Exhaust aerosol from gasoline passenger cars is a complex mixture of a particulate fraction as well as volatile compounds. In contrary to the observed adverse effects of diesel exhaust particles the gasoline exhaust has, however, received little attention so far. The aim of this study was to perform a comparison of exhaust composition and biological responses from freshly produced...

Université de Fribourg

Biomedical nanoparticles modulate specific CD4+ T cell stimulation by inhibition of antigen processing in dendritic cells

Blank, Fabian ; Gerber, Peter ; Rothen-Rutishauser, Barbara ; Sakulkhu, Usawadee ; Salaklang, Jatuporn ; Peyer, Karin De ; Gehr, Peter ; Nicod, Laurent P. ; Hofmann, Heinrich ; Geiser, Thomas ; Petri-Fink, Alke ; Garnier, Christophe Von

In: Nanotoxicology, 2011, p. -

Understanding how nanoparticles may affect immune responses is an essential prerequisite to developing novel clinical applications. To investigate nanoparticle-dependent outcomes on immune responses, dendritic cells (DCs) were treated with model biomedical poly(vinylalcohol)-coated super-paramagnetic iron oxide nanoparticles (PVA-SPIONs). PVA-SPIONs uptake by human monocyte-derived DCs (MDDCs)...