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Université de Fribourg

Nutrition, movement and sleep behaviours: their interactions in pathways to obesity and cardiometabolic diseases

Dulloo, Abdul G. ; Miles-Chan, Jennifer L. ; Montani, Jean-Pierre

In: Obesity Reviews, 2017, vol. 18, no. S1, p. 3–6

Among the multitude of dietary and lifestyle behaviours that have been proposed to contribute to the obesity epidemic, those that have generated considerable research scrutiny in the past decade are centred upon sleep behaviours, sedentary behaviours (sitting or lying while awake) and diminished low-level physical activities of everyday life, with each category of behaviours apparently...

Université de Fribourg

Translational issues in targeting brown adipose tissue thermogenesis for human obesity management

Dulloo, Abdul G.

In: Annals of the New York Academy of Sciences, 2013, vol. 1302, no. 1, p. 1–10

The recent advancements in unraveling novel mechanisms that control the induction, (trans)differentiation, proliferation, and thermogenic activity and capacity of brown adipose tissue (BAT), together with the application of imaging techniques for human BAT visualization, have generated optimism that these advances will provide novel strategies for targeting BAT thermogenesis, leading to...

Université de Fribourg

Body composition, inflammation and thermogenesis in pathways to obesity and the metabolic syndrome: an overview

Dulloo, Abdul G. ; Montani, Jean-Pierre

In: Obesity Reviews, 2012, vol. 13, no. S2, p. 1–5

According to the World Health Organization, overweight and obesity are defined as abnormal or excessive fat accumulation that presents a risk to health. What constitutes ‘abnormal’ fat accumulation in this definition is not specified, but this most likely represents a consensus term that encapsulates the importance of adipose tissue dysfunctions, rather than solely excess fat per se, in the...

Université de Fribourg

Body composition phenotypes in pathways to obesity and the metabolic syndrome

Dulloo, Abdul G. ; Jacquet, Jean ; Solinas, Giovanni ; Montani, Jean-Pierre ; Schutz, Y.

In: International Journal of Obesity, 2010, vol. 34, p. S4–S17

Dynamic changes in body weight have long been recognized as important indicators of risk for debilitating diseases. While weight loss or impaired growth can lead to muscle wastage, as well as to susceptibility to infections and organ dysfunctions, the development of excess fat predisposes to type 2 diabetes and cardiovascular diseases, with insulin resistance as a central feature of the disease...