Université de Fribourg

Thrifty metabolism that favors fat storage after caloric restriction: a role for skeletal muscle phosphatidylinositol-3-kinase activity and AMP-activated protein kinase

Summermatter, Serge ; Mainieri, Davide ; Russell, A. P. ; Seydoux, Josiane ; Montani, Jean-Pierre ; Buchala, Anthony J. ; Solinas, Giovanni ; Dulloo, Abdul G.

In: Faseb Journal, 2008, vol. 22, p. 774-785

Energy conservation directed at accelerating body fat recovery (or catch-up fat) contributes to obesity relapse after slimming and to excess fat gain during catch-up growth after malnutrition. To investigate the mechanisms underlying such thrifty metabolism for catch-up fat, we tested whether during refeeding after caloric restriction rats exhibiting catch-up fat driven by suppressed...

Université de Fribourg

Regulation of fat storage via suppressed thermogenesis: a thrifty phenotype that predisposes individuals with catch-up growth to insulin resistance and obesity

Dulloo, Abdul G.

In: Hormone Research, 2006, vol. 65(suppl 3), p. 90–97

Catch-up growth during infancy and childhood is increasingly recognized as a major risk factor for later development of insulin-related complications and chronic diseases, namely abdominal obesity, type 2 diabetes and cardiovascular disease. As catch-up growth per se is characterized by insulin resistance, hyperinsulinaemia and an accelerated rate of fat storage (i.e., catch-up fat) even in the...