In: Obesity Reviews, 2012, vol. 13, no. S2, p. 1–5
According to the World Health Organization, overweight and obesity are defined as abnormal or excessive fat accumulation that presents a risk to health. What constitutes ‘abnormal’ fat accumulation in this definition is not specified, but this most likely represents a consensus term that encapsulates the importance of adipose tissue dysfunctions, rather than solely excess fat per se, in the...
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In: International Journal of Obesity, 2007, vol. 31, no. 2, p. 378–381
Mice lacking β-adrenoceptors, which mediate the thermogenic effects of norepinephrine and epinephrine, show diminished thermogenesis and high susceptibility to obesity, whereas mice lacking stearoyl-CoA desaturase 1 (SCD1), which catalyzes the synthesis of monounsaturated fatty acids, show enhanced thermogenesis and high resistance to obesity. In testing whether β-adrenergic...
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In: Hormone Research, 2006, vol. 65, no. 3, p. 90-97
Catch-up growth during infancy and childhood is increasingly recognized as a major risk factor for later development of insulin-related complications and chronic diseases, namely abdominal obesity, type 2 diabetes and cardiovascular disease. As catch-up growth per se is characterized by insulin resistance, hyperinsulinaemia and an accelerated rate of fat storage (i.e., catch-up fat) even in...
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