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Université de Fribourg

Reliability of low‐power cycling efficiency in energy expenditure phenotyping of inactive men and women

Fares, Elie-Jacques ; Isacco, Laurie ; Monnard, Cathriona R. ; Miles-Chan, Jennifer L. ; Montani, Jean-Pierre ; Schutz, Yves ; Dulloo, Abdul G.

In: Physiological Reports, 2017, vol. 5, no. 9, p. e13233

Standardized approaches to assess human energy expenditure (EE) are well defined at rest and at moderate to high‐intensity exercise, but not at light intensity physical activities energetically comparable with those of daily life (i.e., 1.5–4 times the resting EE, i.e., 1.5–4 METs). Our aim was to validate a graded exercise test for assessing the energy cost of low‐intensity dynamic...

Université de Fribourg

Polyunsaturated fatty acids stimulate de novo lipogenesis and improve glucose homeostasis during refeeding with high fat diet

Crescenzo, Raffaella ; Mazzoli, Arianna ; Cancelliere, Rosa ; Bianco, Francesca ; Giacco, Antonia ; Liverini, Giovanna ; Dulloo, Abdul G. ; Iossa, Susanna

In: Frontiers in Physiology, 2017, vol. 8, p. -

The recovery of body weight after a period of caloric restriction is accompanied by an enhanced efficiency of fat deposition and hyperinsulinemia—which are exacerbated by isocaloric refeeding on a high fat diet rich in saturated and monounsaturated fatty acids (SFA-MUFA), and poor in polyunsaturated fatty acids (PUFA), and associated with a blunting of de novo lipogenesis in adipose tissue...

Université de Fribourg

Postprandial hypotension in older adults: Can it be prevented by drinking water before the meal?

Grobéty, Bastien ; Grasser, Erik Konrad ; Yepuri, Gayathri ; Dulloo, Abdul G. ; Montani, Jean-Pierre

In: Clinical Nutrition, 2015, vol. 34, no. 5, p. 885–891

Background & aimsAn important consequence of ageing is a tendency for postprandial blood pressure to decline, which can lead to fainting. As a possible countermeasure, we investigated in healthy older adults the impact of drinking water before a breakfast meal on postprandial cardiovascular and autonomic functions.MethodsAfter a stable cardiovascular baseline recording for at least 20 min,...

Université de Fribourg

Pathways from dieting to weight regain, to obesity and to the metabolic syndrome: an overview

Dulloo, Abdul G. ; Montani, Jean-Pierre

In: Obesity Reviews, 2015, vol. 16, p. 1–6

Every year, scores of millions of people – as diverse as obese and lean, teenagers and older adults, sedentary and elite athletes, commoners and celebrities – attempt to lose weight on some form of diet. They are often encouraged by their parents, friends, health professionals, training coaches, a media that promotes a slim image and a diet- industry that in Europe and United States alone...

Université de Fribourg

The thermic effect of sugar-free Red Bull: Do the non-caffeine bioactive ingredients in energy drinks play a role?

Miles-Chan, Jennifer L. ; Charrière, Nathalie ; Grasser, Erik K ; Montani, Jean-Pierre ; Dulloo, Abdul G.

In: Obesity, 2015, vol. 23, no. 1, p. 16–19

Objective: Consumption of energy drinks is increasing amongst athletes and the general public. By virtue of their bioactive ingredients (including caffeine, taurine, glucuronolactone, and B-group vitamins) and paucity of calories, sugar-free “diet” versions of these drinks could be a useful aid for weight maintenance. Yet little is known about the acute influence of these drinks, and...

Université de Fribourg

How dieting makes the lean fatter: from a perspective of body composition autoregulation through adipostats and proteinstats awaiting discovery

Dulloo, Abdul G. ; Jacquet, Jean ; Montani, Jean-Pierre ; Schutz, Yves

In: Obesity Reviews, 2015, vol. 16, p. 25–35

Whether dieting makes people fatter has been a subject of considerable controversy over the past 30 years. More recent analysis of several prospective studies suggest, however, that it is dieting to lose weight in people who are in the healthy normal range of body weight, rather than in those who are overweight or obese, that most strongly and consistently predict future weight gain. This paper...

Université de Fribourg

Dieting and weight cycling as risk factors for cardiometabolic diseases: who is really at risk?

Montani, Jean-Pierre ; Schutz, Yves ; Dulloo, Abdul G.

In: Obesity Reviews, 2015, vol. 16, p. 7–18

Despite the poor prognosis of dieting in obesity management, which often results in repeated attempts at weight loss and hence weight cycling, the prevalence of dieting has increased continuously in the past decades in parallel to the steadily increasing prevalence of obesity. However, dieting and weight cycling are not limited to those who are obese or overweight as substantial proportions of...

Université de Fribourg

Cardiovascular and metabolic responses to tap water ingestion in young humans: does the water temperature matter?

Girona, M. ; Grasser, Erik Konrad ; Dulloo, Abdul G. ; Montani, Jean-Pierre

In: Acta Physiologica, 2014, vol. 211, no. 2, p. 358–370

Aim: Drinking water induces short-term cardiovascular and metabolic changes. These effects are considered to be triggered by gastric distension and osmotic factors, but little is known about the influence of water temperature.Methods: We determined, in a randomized crossover study, the acute cardiovascular and metabolic responses to 500 mL of tap water at 3 °C (cold), 22 °C (room) and...

Université de Fribourg

Cardio- and cerebrovascular responses to the energy drink Red Bull in young adults: a randomized cross-over study

Grasser, Erik K. ; Yepuri, Gayathri ; Dulloo, Abdul G. ; Montani, Jean-Pierre

In: European Journal of Nutrition, 2014, p. 1–11

Purpose: Energy drinks are beverages containing vasoactive metabolites, usually a combination of caffeine, taurine, glucuronolactone and sugars. There are concerns about the safety of energy drinks with some countries banning their sales. We determined the acute effects of a popular energy drink, Red Bull, on cardiovascular and hemodynamic variables, cerebrovascular parameters and...

Université de Fribourg

Sitting comfortably versus lying down: Is there really a difference in energy expenditure?

Miles-Chan, Jennifer Lynn ; Sarafian, Delphine ; Montani, Jean-Pierre ; Schutz, Yves ; Dulloo, Abdul G.

In: Clinical Nutrition, 2014, vol. 33, no. 1, p. 175–178

Background and aims: Energy expenditure (EE) during sitting is widely assumed to be higher than that while lying down, but supporting evidence is equivocal. Despite this, resting EE in the sitting position is often used as a proxy for basal metabolic rate. Here we investigate whether EE differs in the comfortable seated position compared to supine (lying) position.Methods: EE and respiratory...