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Université de Fribourg

Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balance

Dulloo, Abdul G. ; Seydoux, Josiane ; Jacquet, Jean

In: Physiology & Behavior, 2004, vol. 83(4), p. 587-602

After decades of controversies about the quantitative importance of autoregulatory adjustments in energy expenditure in weight regulation, there is now increasing recognition that even subtle variations in thermogenesis could, in dynamic systems and over the long term, be important in determining weight maintenance in some and obesity in others. The main challenge nowadays is to provide a...

Université de Fribourg

Cardio- and cerebrovascular responses to the energy drink Red Bull in young adults: a randomized cross-over study

Grasser, Erik K. ; Yepuri, Gayathri ; Dulloo, Abdul G. ; Montani, Jean-Pierre

In: European Journal of Nutrition, 2014, p. 1–11

Purpose: Energy drinks are beverages containing vasoactive metabolites, usually a combination of caffeine, taurine, glucuronolactone and sugars. There are concerns about the safety of energy drinks with some countries banning their sales. We determined the acute effects of a popular energy drink, Red Bull, on cardiovascular and hemodynamic variables, cerebrovascular parameters and microvascular...

Université de Fribourg

Cardiovascular and metabolic responses to tap water ingestion in young humans: does the water temperature matter?

Girona, M. ; Grasser, Erik Konrad ; Dulloo, Abdul G. ; Montani, Jean-Pierre

In: Acta Physiologica, 2014, vol. 211, no. 2, p. 358–370

Aim: Drinking water induces short-term cardiovascular and metabolic changes. These effects are considered to be triggered by gastric distension and osmotic factors, but little is known about the influence of water temperature.Methods: We determined, in a randomized crossover study, the acute cardiovascular and metabolic responses to 500 mL of tap water at 3 °C (cold), 22 °C (room) and...

Université de Fribourg

Cardiovascular responses to sugary drinks in humans: galactose presents milder cardiac effects than glucose or fructose

Charrière, Nathalie ; Loonam, Cathriona ; Montani, Jean-Pierre ; Dulloo, Abdul G. ; Grasser, Erik K.

In: European Journal of Nutrition, 2017, vol. 56, no. 6, p. 2105–2113

PurposeThere is increasing interest into the potentially beneficial effects of galactose for obesity and type 2 diabetes management as it is a low-glycemic sugar reported to increase satiety and fat mobilization. However, fructose is also a low-glycemic sugar but with greater blood pressure elevation effects than after glucose ingestion. Therefore, we investigated here the extent to which the...

Université de Fribourg

Comment les régimes amaigrissants font grossir : d’une perspective d’autorégulation de la composition corporelle = How dieting makes some fatter: From a perspective of human body composition autoregulation

Dulloo, Abdul G. ; Jacquet, Jean ; Seydoux, Josiane ; Montani, Jean-Pierre

In: Cahiers de Nutrition et de Diététique, 2013, vol. 48, no. 1, p. 15–25

Le titre d’un livre publié en 1983 ‘Dieting Makes You Fat’ – concrétise la notion que faire un régime pour contrôler son poids, et par conséquent l’effet yo-yo, prédispose l’individu à être encore plus gras. Alors que cette notion est controversée, son débat souligne le fossé qui existe dans notre compréhension des lois fondamentales de la physiologie qui gouvernent la...

Université de Fribourg

The contribution of Swiss scientists to the assessment of energy metabolism

Montani, Jean-Pierre ; Schutz, Yves ; Dulloo, Abdul G.

In: European Journal of Clinical Nutrition, 2018, vol. 72, no. 5, p. 665–679

Although Switzerland is considered a small country, it has its share in discoveries, inventions and developments for the assessment of energy metabolism. This includes seminal contributions to respiratory and metabolic physiology and to devices for measuring energy expenditure by direct and indirect calorimetry in vivo in humans and small animals (as well as in vitro in organs/tissues), for...

Université de Fribourg

Corticotropin-Releasing Hormone directly stimulates thermogenesis in skeletal muscle possibly through substrate cycling between de novo lipogenesis and lipid oxidation

Solinas, Giovanni ; Summermatter, Serge ; Mainieri, Davide ; Gubler, Marcel ; Montani, Jean-Pierre ; Seydoux, Josiane ; Smith, S. R. ; Dulloo, Abdul G.

In: Endocrinology, 2006, vol. 147(1), p. 31-38

The mechanisms by which CRH and related peptides (i.e. the CRH/urocortin system) exert their control over thermogenesis and weight regulation have until now focused only upon their effects on brain centers controlling sympathetic outflow. Using a method that involves repeated oxygen uptake determinations in intact mouse skeletal muscle, we report here that CRH can act directly on skeletal...

Université de Fribourg

Dieting and weight cycling as risk factors for cardiometabolic diseases: who is really at risk?

Montani, Jean-Pierre ; Schutz, Yves ; Dulloo, Abdul G.

In: Obesity Reviews, 2015, vol. 16, p. 7–18

Despite the poor prognosis of dieting in obesity management, which often results in repeated attempts at weight loss and hence weight cycling, the prevalence of dieting has increased continuously in the past decades in parallel to the steadily increasing prevalence of obesity. However, dieting and weight cycling are not limited to those who are obese or overweight as substantial proportions of...