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Université de Fribourg

Telmisartan prevents the glitazone-induced weight gain without interfering with its insulin-sensitizing properties

Zanchi, Anne ; Dulloo, Abdul G. ; Perregaux, Christine ; Montani, Jean-Pierre ; Burnier, Michel

In: American Journal of Physiology - Endocrinology and Metabolism, 2007, vol. 293, p. E91-E95

Glitazones are peroxisome proliferator-activated receptor (PPAR)-Γ agonists with powerful insulin-sensitizing properties. They promote the development of metabolically active adipocytes that can lead to a substantial gain in fat mass. Telmisartan is an ANG II type 1 receptor antagonist with partial PPAR-Γ agonistic properties. Recently, telmisartan has been reported to prevent weight gain and...

Université de Fribourg

Weight cycling during growth and beyond as a risk factor for later cardiovascular diseases: the 'repeated overshoot' theory

Montani, Jean-Pierre ; Viecelli, A. K. ; Prévot, Anne ; Dulloo, Abdul G.

In: International Journal of Obesity, 2006, vol. 30, no. S4, p. S58–S66

In people trying to lose weight, there are often repeated cycles of weight loss and regain. Weight cycling is, however, not limited to obese adults but affects people of normal weight, particularly young women, who are unhappy with their appearance. Furthermore, the onset of a pattern of weight cycling is shifting towards younger ages, owing to the increasing prevalence of overweight and obesity...

Université de Fribourg

The thrifty 'catch-up fat' phenotype: its impact on insulin sensitivity during growth trajectories to obesity and metabolic syndrome

Dulloo, Abdul G. ; Jacquet, Jean ; Seydoux, Josiane ; Montani, Jean-Pierre

In: International Journal of Obesity, 2006, vol. 30, no. S4, p. S23–S35

The analyses of large epidemiological databases have suggested that infants and children who show catch-up growth, or adiposity rebound at a younger age, are predisposed to the development of obesity, type 2 diabetes and cardiovascular diseases later in life. The pathophysiological mechanisms by which these growth trajectories confer increased risks for these diseases are obscure, but there is...

Université de Fribourg

A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesis

Mainieri, Davide ; Summermatter, Serge ; Seydoux, Josiane ; Montani, Jean-Pierre ; Rusconi, Sandro ; Russell, Aaron P. ; Boss, Olivier ; Buchala, Antony J. ; Dulloo, Abdul G.

In: The FASEB Journal, 2006, vol. 20, no. 10, p. 1751-1753

An enhanced metabolic efficiency for accelerating the recovery of fat mass (or catch-up fat) is a characteristic feature of body weight regulation after weight loss or growth retardation and is the outcome of an "adipose-specific" suppression of thermogenesis, i.e., a feedback control system in which signals from the depleted adipose tissue fat stores exert a suppressive effect on thermogenesis....

Université de Fribourg

Corticotropin-Releasing Hormone directly stimulates thermogenesis in skeletal muscle possibly through substrate cycling between de novo lipogenesis and lipid oxidation

Solinas, Giovanni ; Summermatter, Serge ; Mainieri, Davide ; Gubler, Marcel ; Montani, Jean-Pierre ; Seydoux, Josiane ; Smith, S. R. ; Dulloo, Abdul G.

In: Endocrinology, 2006, vol. 147(1), p. 31-38

The mechanisms by which CRH and related peptides (i.e. the CRH/urocortin system) exert their control over thermogenesis and weight regulation have until now focused only upon their effects on brain centers controlling sympathetic outflow. Using a method that involves repeated oxygen uptake determinations in intact mouse skeletal muscle, we report here that CRH can act directly on skeletal...

Université de Fribourg

Regulation of fat storage via suppressed thermogenesis: a thrifty phenotype that predisposes individuals with catch-up growth to insulin resistance and obesity

Dulloo, Abdul G.

In: Hormone Research, 2006, vol. 65(suppl 3), p. 90–97

Catch-up growth during infancy and childhood is increasingly recognized as a major risk factor for later development of insulin-related complications and chronic diseases, namely abdominal obesity, type 2 diabetes and cardiovascular disease. As catch-up growth per se is characterized by insulin resistance, hyperinsulinaemia and an accelerated rate of fat storage (i.e., catch-up fat) even in the...

Université de Fribourg

Substrate cycling between de novo lipogenesis and lipid oxidation: a thermogenic mechanism against skeletal muscle lipotoxicity and glucolipotoxicity

Dulloo, Abdul G. ; Gubler, Marcel ; Montani, Jean-Pierre ; Seydoux, Josiane ; Solinas, Giovanni

In: International Journal of Obesity, 2004, vol. 28 (Suppl. 4), p. S29-S37

Life is a combustion, but how the major fuel substrates that sustain human life compete and interact with each other for combustion has been at the epicenter of research into the pathogenesis of insulin resistance ever since Randle proposed a 'glucose-fatty acid cycle' in 1963. Since then, several features of a mutual interaction that is characterized by both reciprocality and dependency between...

Université de Fribourg

Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases

Montani, Jean-Pierre ; Carroll, Joan F. ; Dwyer, Terry M. ; Antic, Vladan ; Yang, Zhihong ; Dulloo, Abdul G.

In: International Journal of Obesity, 2004, vol. 28, p. S58-65

In humans and most animal models, the development of obesity leads not only to increased fat depots in classical adipose tissue locations but also to significant lipid deposits within and around other tissues and organs, a phenomenon known as ectopic fat storage. The purpose of this review is to explore the possible locations of ectopic fat in key target-organs of cardiovascular control (heart,...

Université de Fribourg

Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balance

Dulloo, Abdul G. ; Seydoux, Josiane ; Jacquet, Jean

In: Physiology & Behavior, 2004, vol. 83(4), p. 587-602

After decades of controversies about the quantitative importance of autoregulatory adjustments in energy expenditure in weight regulation, there is now increasing recognition that even subtle variations in thermogenesis could, in dynamic systems and over the long term, be important in determining weight maintenance in some and obesity in others. The main challenge nowadays is to provide a...