Perfeziona i miei risultati

Document type


Collection spécifique




Parola chiave

    Université de Fribourg

    αENaC mediated lithium absorption promotes nephrogenic diabetes insipidus

    Mønster Christensen, Birgitte ; Mercier Zuber, Annie ; Loffing, Johannes ; Stehle, Jean-Christophe ; Deen, Peter M.T. ; Rossier, Bernard C. ; Hummler, Edith

    In: Journal of the American Society of Nephrology, 2010, vol. 21, p. -

    Lithium-induced nephrogenic diabetes insipidus (NDI) is accompanied by polyuria, downregulation of aquaporin 2 (AQP2), and cellular remodeling of the collecting duct (CD). The amiloride-sensitive epithelial sodium channel (ENaC) is a likely candidate for lithium entry. Here, we subjected transgenic mice lacking αENaC specifically in the CD (knockout [KO] mice) and littermate controls to chronic...