Université de Fribourg

Structure and development of the subesophageal zone of the Drosophila brain. II. Sensory compartments

Kendroud, Sarah ; Bohra, Ali A. ; Kuert, Philipp A. ; Nguyen, Bao ; Guillermin, Oriane ; Sprecher, Simon G. ; Reichert, Heinrich ; VijayRaghavan, Krishnaswamy ; Hartenstein, Volker

In: Journal of Comparative Neurology, 2018, vol. 526, no. 1, p. 33–58

The subesophageal zone (SEZ) of the Drosophila brain processes mechanosensory and gustatory sensory input from sensilla located on the head, mouth cavity and trunk. Motor output from the SEZ directly controls the movements involved in feeding behavior. In an accompanying paper (Hartenstein et al., 2017), we analyzed the systems of fiber tracts and secondary lineages to establish reliable...

Université de Fribourg

Role for glutathione in the hyposensitivity of LPS-pretreated mice to LPS anorexia

Hernadfalvi, Noemi ; Langhans, Wolfgang ; Meyenburg, Claudia von ; Onteniente, Brigitte ; Richard, Denis ; Arsenijevic, Denis

In: European Cytokine Network, 2007, vol. 18, no. 2, p. 39-45

To study the role of the redox state regulator glutathione (GSH) in bacterial lipopolysaccharide (LPS)-induced anorexia we measured GSH in liver, serum and brain in response to intraperitoneal (ip) lipopolysaccharide (LPS, 4μg/mouse) injection in LPS-naïve and LPS-pretreated (4 μg/mouse) mice. LPS reduced food intake in LPS-naïve mice and LPS pretreatment attenuated this effect. LPS...

Université de Fribourg

Role for nerve growth factor in the in vivo regulation of glutathione in response to LPS in mice

Arsenijevic, Denis ; Hernadfalvi, Noemi ; Meyenburg, Claudia von ; Onteniente, Brigitte ; Richard, Denis ; Langhans, Wolfgang

In: European Cytokine Network, 2007, vol. 18, no. 2, p. 47-55

Since the redox state regulator glutathione (GSH) influences lipopolysaccharide (LPS) anorexia, we studied the roles of tumour necrosis factor-alpha (TNFα) and nerve growth factor (NGF) in the GSH response to intraperitoneal (ip) LPS injection in mice. Basal NGF and GSH levels were up-regulated in brain and liver of TNFα-knock-out (KO) mice, and this was associated with attenuated LPS anorexia....

Université de Fribourg

Induction of Ucp2 expression in brain phagocytes and neurons following murine toxoplasmosis: An essential role of IFN-γ and an association with negative energy balance

Arsenijevic, Denis ; Clavel, Sébastien ; Sanchis, Daniel ; Plamondon, Julie ; Huang, Quingling ; Ricquier, Daniel ; Rouger, Laurie ; Richard, Denis

In: Journal of Neuroimmunology, 2007, vol. 186, no. 1-2, p. 121-132

A model of murine toxoplasmosis was used to study cellular and temporal expression of uncoupling protein-2 (Ucp2) in the brain. In situ hybridization indicated that Ucp2 was located in neurons. Nuclei structures involved in energy balance, in particular the nucleus of the solitary tract (NST), was shown to have a positive association between negative energy balance and...