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Università della Svizzera italiana

Increasing cancer risk over calendar year in people with multiple sclerosis : a case–control study

Zecca, Chiara ; Disanto, Giulio ; Sacco, Rosaria ; MacLachlan, Sharon ; Kuhle, Jens ; Ramagopalan, Sreeram V. ; Gobbi, Claudio

In: Journal of Neurology, 2021, no. 268, p. 817–824

Background: Data on cancer prevalence and incidence in multiple sclerosis (MS) patients are controversial. This study is aimed at estimating cancer risk in MS patients. Methods: Nested case–control study using data collected between 01/01/1987 and 28/02/2016 from the United Kingdom Clinical Practice Research Datalink. Cancer diagnoses after first MS code (index date) was counted in 10,204 MS...

Università della Svizzera italiana

The prospect and challenges to the flow of liquid biopsy in Africa

Oluwaseyi Temilola, Dada ; Wium, Martha ; Coulidiati, Tangbadioa Herve ; Adeola, Henry Ademola ; Carbone, Giuseppina Maria ; Catapano, Carlo Vittorio Institute of Oncology Research (IOR), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland ; Zerbini, Luiz Fernando

In: Cells, 2019, vol. 8, no. 8, p. 862

Liquid biopsy technologies have the potential to transform cancer patient management as it others non- invasive diagnosis and real-time monitoring of disease progression and treatment responses. The use of liquid biopsy for non-invasive cancer diagnosis can have pivotal importance for the African continent where access to medical infrastructures is limited, as it eliminates the need for...

Università della Svizzera italiana

Structural biology of STAT3 and its implications for anticancer therapies development

Sgrignani, Jacopo ; Garofalo, Maura ; Matkovic, Milos ; Merulla, Jessica ; Catapano, Carlo V. ; Cavalli, Andrea

In: International journal of molecular sciences, 2018, vol. 19, no. 6, p. 1591

Transcription factors are proteins able to bind DNA and induce the transcription of specific genes. Consequently, they play a pivotal role in multiple cellular pathways and are frequently over-expressed or dysregulated in cancer. Here, we will focus on a specific “signal transducer and activator of transcription” (STAT3) factor that is involved in several pathologies, including cancer....