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Telmisartan prevents the glitazone-induced weight gain without interfering with its insulin-sensitizing properties

Zanchi, Anne ; Dulloo, Abdul G. ; Perregaux, Christine ; Montani, Jean-Pierre ; Burnier, Michel

In: American Journal of Physiology - Endocrinology and Metabolism, 2007, vol. 293, p. E91-E95

Glitazones are peroxisome proliferator-activated receptor (PPAR)-Γ agonists with powerful insulin-sensitizing properties. They promote the development of metabolically active adipocytes that can lead to a substantial gain in fat mass. Telmisartan is an ANG II type 1 receptor antagonist with partial PPAR-Γ agonistic properties. Recently, telmisartan has been reported to prevent weight gain and...