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Université de Fribourg

Tautomerism in azo dyes: Border cases of azo and hydrazo tautomers as possible NMR reference compounds

Deneva, Vera ; Lyčka, Antonin ; Hristova, S. ; Crochet, Aurélien ; Fromm, Katharina M. ; Antonov, Liudmil M.

In: Dyes and Pigments, 2019, vol. 165, p. 157–163

In order to meet the need for NMR reference compounds in the study of tautomeric azo dyes, two series of azo dyes, derived from 3-methyl-1-phenyl-4- (phenyldiazenyl)-1H-pyrazol-5-amine and 5-methyl-2-phenyl-4-(2- phenylhydrazono)-2,4-dihydro-3H-pyrazol-3-one, have been studied by using molecular spectroscopy (UV–Vis and NMR) and quantum-chemical calculations (M06- 2X/TZVP) in solution. The...

Université de Fribourg

Synthesis and applications of nanocontainers and nanorattles

Abram, Sarah-Luise ; Yep, Philippe ; Fromm, Katharina M.

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 12–16

Nanorattles and hollow nanocontainers have unique properties related to the presence of a void space inside the shell, which has been shown to improve the properties of materials for e.g. catalysis, drug release, sensor materials or lithium ion batteries. This article summarizes our recent progress in the synthesis of hollow silica, titania and ceria nanorattles and nanocontainers, eventually...

Université de Fribourg

Prospect for supramolecular chemistry in high-energy-density rechargeable batteries

Kwon, Tae-woo ; Choi, Jang Wook ; Coskun, Ali

In: Joule, 2019, vol. 3, no. 3, p. 662–682

The quest for new electrode materials for Li-ion batteries with high energy densities beyond conventional intercalation-based electrodes has gained significant attention due to the increasing demand for advanced portable devices and electric vehicles (EVs). Among various candidates, the most promising electrode materials along this direction are silicon and Li metal for anodes and sulfur for...

Université de Fribourg

Secondary metabolites from Triclisia gilletii (De Wild) Staner (Menispermaceae) with antimycobacterial activity against Mycobacterium tuberculosis

Tiam, Eric Robert ; Ngono Bikobo, Dominique Serge ; Zintchem, Auguste Abouem A. ; Mbabi Nyemeck II, Norbert ; Moni Ndedi, Esther Del Florence ; Betote Diboué, Patrick Hervé ; Nyegue, Maximilienne Ascension ; Atchadé, Alex de Théodore ; Pegnyemb, Dieudonné Emmanuel ; Bochet, Christian G. ; Koert, Ulrich

In: Natural Product Research, 2019, vol. 33, no. 5, p. 642–650

Triclisinone (2), a new ochnaflavone derivative, was isolated from the aerial parts of Triclisia gilletii, along with known drypemolundein B (1) and eight other known compounds. The chemical shifts of drypemolundein B (1) have been partially revised based on reinterpretation of NMR spectroscopic data. The eight other secondary metabolites are composed of: (+)-nonacosan-10-ol (3); stigmasterol...

Université de Fribourg

Modification of sperm fatty acid composition during epididymal maturation in bats

Fasel, Nicolas J. ; McMillian, Kevin ; Jakop, Ulrike ; Méné-Saffrané, Laurent ; Engel, Kathrin M. ; Genoud, Michel ; Müller, Karin ; Christe, Philippe

In: Reproduction, 2019, vol. 157, no. 1, p. 77–85

Biochemical properties of polyunsaturated fatty acids (PUFAs) are fundamental to sperm movements. Amongst all adjustments operated during epididymal maturation, sperm membrane lipid composition is remodelled. Specifically, the proportion of PUFAs usually increases from the caput towards the cauda epididymidis. In mammals, PUFAs are predominantly acquired through the diet, which can ...

Université de Fribourg

A spatially and functionally distinct pool of TORC1 defines signaling endosomes in yeast

Hatakeyama, Riko ; De Virgilio, Claudio

In: Autophagy, 2019, vol. 15, no. 5, p. 915–916

The evolutionarily conserved target of rapamycin complex 1 (TORC1) regulates cell growth in a homeostatic manner by tuning anabolic and catabolic processes in response to nutritional and hormonal cues. Interestingly, rather than being localized at the plasma membrane as perhaps expected for an integrator of extracellular signals, TORC1 mainly localizes at vacuolar (in yeast) and lysosomal (in...

Université de Fribourg

An atomistic look into bio-inspired nanoparticles and their molecular interactions with cells

Petretto, Emanuele ; Campomanes, Pablo ; Stellacci, Francesco ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke ; Vanni, Stefano

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 78–80

Nanoparticles (NPs) have sizes that approach those of pathogens and they can interact with the membranes of eukaryotic cells in an analogous fashion. Typically, NPs are taken up by the cell via the plasma membrane by receptor-mediated processes and subsequently interact with various endomembranes. Unlike pathogens, however, NPs lack the remarkable specificity gained during the evolutionary...

Université de Fribourg

Templated assembly of pore-forming peptides in lipid membranes

Fennouri, Aziz ; List, Jonathan ; Dupasquier, Jessica ; Haeni, Laetitia ; Vanni, Stefano ; Rothen-Rutishauser, Barbara ; Mayer, Michael

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 59–62

Pore-forming peptides are of interest due to their antimicrobial activity and ability to form gateways through lipid membranes. Chemical modification of these peptides makes it possible to arrange several peptide monomers into well-defined pore-forming structures using various templating strategies. These templated super-structures can exert antimicrobial activity at significantly lower total...

Université de Fribourg

Valuable carcasses: postmortem preservation of fatty acid composition in heart tissue

Currie, Shannon E. ; Mène-Saffrané, Laurent ; Fasel, Nicolas J.

In: Conservation Physiology, 2019, vol. 7, no. 1, p. -

In order to effectively conserve species, we must understand the structure and function of integral mechanisms at all levels of organismal organisation, from intracellular biochemistry to whole animal ecophysiology. The accuracy of biochemical analyses depend on the quality and integrity of the samples analysed. It is believed that tissue samples collected immediately postmortem provide the...

Université de Fribourg

Tsr4 and Nap1, two novel members of the ribosomal protein chaperOME

Rössler, Ingrid ; Embacher, Julia ; Pillet, Benjamin ; Murat, Guillaume ; Liesinger, Laura ; Hafner, Jutta ; Unterluggauer, Julia Judith ; Birner-Gruenberger, Ruth ; Kressler, Dieter ; Pertschy, Brigitte

In: Nucleic Acids Research, 2019, p. gkz317

Dedicated chaperones protect newly synthesized ribosomal proteins (r-proteins) from aggregation and accompany them on their way to assembly into nascent ribosomes. Currently, only nine of the ∼80 eukaryotic r-proteins are known to be guarded by such chaperones. In search of new dedicated r-protein chaperones, we performed a tandem-affinity purification based screen and looked for factors...