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Université de Fribourg

The Evolution of Aging

Fabian, Daniel ; Flatt, Thomas

In: Nature Education Knowledge, 2011, vol. 3, no. 3, p. 1-10

Université de Fribourg

Still Pondering an Age-Old Question

Flatt, Thomas ; Promislow, Daniel E. L.

In: Science, 2007, vol. 318, p. 1255-1256

A theory of trade-offs to explain why we age has spurred 50 years of interdisciplinary research in evolution and molecular genetics.

Université de Fribourg

A role for genetic accommodation in evolution?

Braendle, Christian ; Flatt, Thoams

In: BioEssays, 2006, no. 28, p. 868-873

Whether evolutionary change can occur by genetic assimilation, or more generally by genetic accommodation, remains controversial. Here we examine some of the experimental evidence for both phenomena. Several experiments in Drosophila suggest that assimilation is possible, and a new paper1 shows that a color polyphenism in the tobacco hornworm, Manduca sexta, can evolve by genetic accommodation....

Université de Fribourg

Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history

Flatt, Thomas ; Tu, Meng-Ping ; Tatar, Marc

In: BioEssays, 2005, vol. 27, no. 10, p. 999-1010

Understandinghowtraits are integrated at the organismal level remains a fundamental problem at the interface of developmental and evolutionary biology. Hormones, regulatory signaling molecules that coordinate multiple developmental and physiological processes, are major determinants underlying phenotypic integration. The probably best example for this is the lipid-like juvenile hormone (JH) in...

Consortium of Swiss Academic Libraries

A Computer-Glimpse of the Origin of Life

Kuhn, Christoph

In: Journal of Biological Physics, 2005, vol. 31, no. 3-4, p. 571-585

Consortium of Swiss Academic Libraries

Collagen-like sequences in phages and bacteria

Engel, Juergen ; Bächinger, Hans

In: Proceedings of the Indian Academy of Sciences - Chemical Sciences, 1999, vol. 111, no. 1, p. 81-86

Université de Fribourg

Evolutionary origin of synapses and neurons – Bridging the gap

Burkhardt, Pawel ; Sprecher, Simon G.

In: BioEssays, 2017/39/10/n/a-n/a

The evolutionary origin of synapses and neurons is an enigmatic subject that inspires much debate. Non-bilaterian metazoans, both with and without neurons and their closest relatives already contain many components of the molecular toolkits for synapse functions. The origin of these components and their assembly into ancient synaptic signaling machineries are particularly important in light...