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Université de Fribourg

RTerseaanrchs acrtricileptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

Vogl, Claus ; Flatt, Thomas ; Fuhrmann, Bernd ; Hofmann, Elisabeth ; Wallner, Barbara ; Stiefvater, Rita ; Kovarik, Pavel ; Strobl, Birgit ; Müller, Mathias

In: BMC Genomics, 2010, vol. 11, no. 199, p. 1-19

Background: Tyrosine kinase 2 (Tyk2), a central component of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling, has major effects on innate immunity and inflammation. Mice lacking Tyk2 are resistant to endotoxin shock induced by lipopolysaccharide (LPS), and Tyk2 deficient macrophages fail to efficiently induce interferon alpha/beta after LPS treatment. However,...

Université de Fribourg

De novo expression of parvalbumin in ependymal cells in response to brain injury promotes ependymal remodeling and wound repair

Szabolcsi, Viktória ; Celio, Marco R.

In: Glia, 2014, p. -

The calcium-binding protein parvalbumin (PV) hallmarks subpopulations of interneurons in the murine brain. We serendipitously observed the de novo expression of PV in ependymal cells of the lateral ventricle wall following in vivo lesioning and brain slicing for the preparation of organotypic hippocampal slice cultures (OHSCs). In OHSCs, de novo PV-expression begins shortly after the onset of...

Université de Fribourg

A comparative study of different in vitro lung cell culture systems to assess the most beneficial tool for screening the potential adverse effects of carbon nanotubes

Clift, Martin J. D. ; Endes, Carola ; Vanhecke, Dimitri ; Wick, Peter ; Gehr, Peter ; Schins, Roel P. F. ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Toxicological Sciences, 2014, vol. 137, no. 1, p. 55–64

To determine the potential inhalatory risk posed by carbon nanotubes (CNTs), a tier-based approach beginning with an in vitro assessment must be adopted. The purpose of this study therefore was to compare 4 commonly used in vitro systems of the human lung (human blood monocyte-derived macrophages [MDM] and monocyte-derived dendritic cells [MDDC], 16HBE14o- epithelial cells, and...

Université de Fribourg

Acute endotoxemia in mice induces downregulation of megalin and cubilin in the kidney

Schreiber, Andrea ; Theilig, Franziska ; Schweda, Frank ; Höcherl, Klaus

In: Kidney International, 2012, p. -

Severe sepsis is often accompanied by acute renal failure with renal tubular dysfunction. Albuminuria is a common finding in septic patients and we studied whether it was due to an impairment of proximal tubular endocytosis of filtered albumin. We studied the regulation of megalin and cubilin, the two critical multiligand receptors responsible for albumin absorption, during severe experimental...

Université de Fribourg

Emerging paradigms and questions on pro-angiogenic bone marrow-derived myelomonocytic cells

Laurent, Julien ; Touvrey, Cédric ; Botta, Francesca ; Kuonen, François ; Ruegg, Curzio

In: The International Journal of Developmental Biology, 2011, vol. 55, p. 527-534

Cancer-related inflammation has emerged in recent years as a major event contributing to tumor angiogenesis, tumor progression and metastasis formation. Bone marrow-derived and inflammatory cells promote tumor angiogenesis by providing endothelial progenitor cells that differentiate into mature endothelial cells, and by secreting pro-angiogenic factors and remodeling the extracellular matrix to...

Université de Fribourg

JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction

Solinas, Giovanni ; Karin, Michael

In: The FASEB Journal, 2010, p. -

Inflammation is thought to underlie the pathogenesis of many chronic diseases. It is now established that obesity results in a state of chronic low-grade inflammation thought to contribute to several metabolic disorders, including insulin resistance and pancreatic islet dysfunction. The protein kinases JNK1 and IKKβ have been found to serve as critical molecular links between obesity, metabolic...

Université de Fribourg

Endothelial-specific deletion of Connexin40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesion

Chadjichristos, C.E. ; Scheckenbach, K.E.L. ; Veen, T.A.B. van ; Richani Sarieddine, M.Z. ; Wit, C. de ; Yang, Zhihong ; Roth, I. ; Bacchetta, M. ; Viswambharan, Hema ; Foglia, B. ; Dudez, T. ; Kempen, M.J.A. van ; Coenjaerts, F.E.J. ; Miquerol, L. ; Deutsch, U. ; Jongsma, H.J. ; Chanson, M. ; Kwak, B.R.

In: Circulation, 2010, vol. 121, p. 123-131

Background— Endothelial dysfunction is the initiating event of atherosclerosis. The expression of connexin40 (Cx40), an endothelial gap junction protein, is decreased during atherogenesis. In the present report, we sought to determine whether Cx40 contributes to the development of the disease.Methods and Results— Mice with ubiquitous deletion of Cx40 are hypertensive, a risk factor for...

Université de Fribourg

O-linked β-N-acetylglucosamine during hyperglycemia exerts both anti-inflammatory and pro-oxidative properties in the endothelial system

Rajapakse, Angana Gupta ; Ming, Xiu-Fen ; Carvas, João Miguel ; Yang, Zhihong

In: Oxidative Medicine & Cellular Longevity, 2009, vol. 2, no. 3, p. 172 - 175

Elevated cellular levels of protein O-linked β-N-acetylglucosamine (O-GlcNAc) through hexosamine biosynthesis pathway (HBP) are suggested to contribute to cardiovascular adverse effects under chronic hyperglycemic condition associated with oxidative stress and inflammation. Conversely, enhancing O-GlcNAc levels have also been demonstrated being protective against myocardial ischemia/reperfusion...