Université de Fribourg

β-Adrenergic control of stearoyl-CoA desaturase 1 repression in relation to sympathoadrenal regulation of thermogenesis

Mainieri, Davide ; Montani, Jean-Pierre ; Seydoux, Josiane ; Giacobino, J. P. ; Boss, O. ; Dulloo, Abdul G.

In: International Journal of Obesity, 2007, vol. 31, no. 2, p. 378–381

Mice lacking β-adrenoceptors, which mediate the thermogenic effects of norepinephrine and epinephrine, show diminished thermogenesis and high susceptibility to obesity, whereas mice lacking stearoyl-CoA desaturase 1 (SCD1), which catalyzes the synthesis of monounsaturated fatty acids, show enhanced thermogenesis and high resistance to obesity. In testing whether β-adrenergic...

Université de Fribourg

Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balance

Dulloo, Abdul G. ; Seydoux, Josiane ; Jacquet, Jean

In: Physiology & Behavior, 2004, vol. 83(4), p. 587-602

After decades of controversies about the quantitative importance of autoregulatory adjustments in energy expenditure in weight regulation, there is now increasing recognition that even subtle variations in thermogenesis could, in dynamic systems and over the long term, be important in determining weight maintenance in some and obesity in others. The main challenge nowadays is to provide a...