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Université de Fribourg

Elucidating the potential biological impact of cellulose nanocrystals

Camarero-Espinosa, Sandra ; Endes, Carola ; Mueller, Silvana ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Weder, Christoph ; Clift, Martin James David ; Foster, E. Johan

In: Fibers, 2016, vol. 4, no. 3, p. 21

Cellulose nanocrystals exhibit an interesting combination of mechanical properties and physical characteristics, which make them potentially useful for a wide range of consumer applications. However, as the usage of these bio-based nanofibers increases, a greater understanding of human exposure addressing their potential health issues should be gained. The aim of this perspective is to...

Université de Fribourg

Decoupling the shape parameter to assess gold nanorod uptake by mammalian cells

Kinnear, Calum ; Rodriguez-Lorenzo, Laura ; Clift, M. J. D. ; Goris, B. ; Bals, S. ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Nanoscale, 2016, vol. 8, no. 36, p. 16416–16426

The impact of nanoparticles (NPs) upon biological systems can be fundamentally associated with their physicochemical parameters. A further often-stated tenet is the importance of NP shape on rates of endocytosis. However, given the convoluted parameters concerning the NP–cell interaction, it is experimentally challenging to attribute any findings to shape alone. Herein we demonstrate that...

Université de Fribourg

Combined exposure of diesel exhaust particles and respirable Soufrière Hills volcanic ash causes a (pro-)inflammatory response in an in vitro multicellular epithelial tissue barrier model

Tomašek, Ines ; Horwell, Claire J. ; Damby, David E. ; Barošová, Hana ; Geers, Christoph ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Clift, Martin J. D.

In: Particle and Fibre Toxicology, 2016, vol. 13, p. 67

There are justifiable health concerns regarding the potential adverse effects associated with human exposure to volcanic ash (VA) particles, especially when considering communities living in urban areas already exposed to heightened air pollution. The aim of this study was, therefore, to gain an imperative, first understanding of the biological impacts of respirable VA when exposed...

Université de Fribourg

Diesel exhaust: current knowledge of adverse effects and underlying cellular mechanisms

Steiner, Sandro ; Bisig, Christoph ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Archives of Toxicology, 2016, p. 1–13

Diesel engine emissions are among the most prevalent anthropogenic pollutants worldwide, and with the growing popularity of diesel-fueled engines in the private transportation sector, they are becoming increasingly widespread in densely populated urban regions. However, a large number of toxicological studies clearly show that diesel engine emissions profoundly affect human health. Thus the...

Université de Fribourg

Engineered nanomaterials: toward effective safety management in research laboratories

Groso, Amela ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Hofmann, Heinrich ; Meyer, Thierry

In: Journal of Nanobiotechnology, 2016, vol. 14, p. 21

It is still unknown which types of nanomaterials and associated doses represent an actual danger to humans and environment. Meanwhile, there is consensus on applying the precautionary principle to these novel materials until more information is available. To deal with the rapid evolution of research, including the fast turnover of collaborators, a user-friendly and easy-to-apply risk...

Université de Fribourg

Plasmonic nanoparticles and their characterization in physiological fluids

Urban, Dominic A. ; Rodriguez-Lorenzo, Laura ; Balog, Sandor ; Kinnear, Calum ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Colloids and Surfaces B: Biointerfaces, 2016, vol. 137, p. 39–49

Nanoparticles possess unique properties beyond that of classical materials, and while these properties can be used for designing a dedicated functionality, they may also pose a problem to living organisms, to human health and the environment. The specific primary routes by which nanoparticles may interact with the human body include inhalation, injection, ingestion and application to the skin....

Université de Fribourg

Distribution of silica-coated silver/gold nanostars in soft- and hardwood applying SERS-based imaging

Geers, Christoph ; Rodríguez-Lorenzo, Laura ; Placencia Peña, M. I. ; Brodard, Pierre ; Volkmer, T. ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Langmuir, 2016, vol. 32, no. 1, p. 274–283

Nanoparticles (NPs) in aqueous suspension have just begun to be exploited for the preservative treatment of wood. However, at present, there is very little information available on the distribution of NPs in wood after impregnation, due to associated analytical challenges. In this study, we present the detection of model NPs in softwood and hardwood by surface-enhanced Raman spectroscopy (SERS)....

Université de Fribourg

Synthesis, characterization, antibacterial activity and cytotoxicity of hollow /TiO₂-coated CeO₂ nanocontainers encapsulating silver nanoparticles for controlled silver release

Gagnon, Jacinthe ; Clift, Martin J. D. ; Vanhecke, Dimitri ; Widnersson, I. E. ; Abram, S.-L. ; Petri-Fink, Alke ; Caruso, R. A. ; Rothen-Rutishauser, Barbara ; Fromm, Katharina M.

In: Journal of Materials Chemistry B, 2016, vol. 4, no. 6, p. 1166–1174

Biomaterials as implants are being applied more extensively in medicine due to their on-going development and associated improvements, and the increase in human life expectancy. Nonetheless, biomaterial-related infections, as well as propagating bacterial resistance, remain significant issues. Therefore, there is a growing interest for silver-based drugs because of their efficient and broad-range...

Université de Fribourg

Formation of drug nanocrystals under nanoconfinement afforded by liposomes

Cipolla, D. ; Wu, H. ; Salentinig, S. ; Boyd, B. ; Rades, T. ; Vanhecke, Dimitri ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Eastman, S. ; Redelmeier, T. ; Gonda, I. ; Chan, H. K.

In: RSC Advances, 2016, vol. 6, no. 8, p. 6223–6233

Nanocrystals of drug substances have important therapeutic applications, but their preparation is often difficult due to size control in bottom up approaches, or energetic milling and surface activation in top down processing. In this study, confinement within liposome nanocompartments is demonstrated to enable drug crystallization with a high aspect ratio but limited growth resulting in...