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Université de Fribourg

Cardiovascular responses to the ingestion of sugary drinks using a randomised cross-over study design : does glucose attenuate the blood pressure-elevating effect of fructose?

Grasser, Erik K. ; Dulloo, Abdul G. ; Montani, Jean-Pierre

In: British Journal of Nutrition, 2014, vol. 112, no. 2, p. 183-192

Overconsumption of sugar-sweetened beverages has been implicated in the pathogenesis of CVD. The objective of the present study was to elucidate acute haemodynamic and microcirculatory responses to the ingestion of sugary drinks made from sucrose, glucose or fructose at concentrations similar to those often found in commercial soft drinks. In a randomised cross-over study design, twelve young...

Université de Fribourg

Cardio- and cerebrovascular responses to the energy drink Red Bull in young adults: a randomized cross-over study

Grasser, Erik K. ; Yepuri, Gayathri ; Dulloo, Abdul G. ; Montani, Jean-Pierre

In: European Journal of Nutrition, 2014, p. 1–11

Purpose: Energy drinks are beverages containing vasoactive metabolites, usually a combination of caffeine, taurine, glucuronolactone and sugars. There are concerns about the safety of energy drinks with some countries banning their sales. We determined the acute effects of a popular energy drink, Red Bull, on cardiovascular and hemodynamic variables, cerebrovascular parameters and...

Université de Fribourg

Interpretation of clinical data and hypothesis testing with the aid of self-collected data from physiology laboratory courses: a teaching approach for medical students

Grasser, Erik Konrad ; Montani, Jean-Pierre

In: Advances in Physiology Education, 2019, vol. 43, no. 4, p. 557–560

More than 50 million scientific articles were published between 1665 and 2009 (4), with millions more expected every year (6). This incomprehensible number accounts for scientific articles alone and does not encompass various “pseudo-scientific” information and articles that are spread, without any peer review process, by social media and blogs, thereby generating a potential source of...

Université de Fribourg

Postprandial hypotension in older adults: Can it be prevented by drinking water before the meal?

Grobéty, Bastien ; Grasser, Erik Konrad ; Yepuri, Gayathri ; Dulloo, Abdul G. ; Montani, Jean-Pierre

In: Clinical Nutrition, 2015, vol. 34, no. 5, p. 885–891

Background & aimsAn important consequence of ageing is a tendency for postprandial blood pressure to decline, which can lead to fainting. As a possible countermeasure, we investigated in healthy older adults the impact of drinking water before a breakfast meal on postprandial cardiovascular and autonomic functions.MethodsAfter a stable cardiovascular baseline recording for at least 20 min,...

Université de Fribourg

Genetic targeting of arginase-ii in mouse prevents renal oxidative stress and inflammation in diet-induced obesity

Huang, Ji ; Rajapakse, Angana ; Xiong, Yuyan ; Montani, Jean-Pierre ; Verrey, François ; Ming, Xiu-Fen ; Yang, Zhihong

In: Frontiers in Physiology, 2016, vol. 7, p. -

Obesity is associated with development and progression of chronic kidney disease (CKD). Recent evidence demonstrates that enhanced levels of the L- arginine:ureahydrolase, including the two isoenzymes arginase-I (Arg-I) and arginase- II (Arg-II) in vascular endothelial cells promote uncoupling of endothelial nitric oxide synthase (eNOS), leading to increased superoxide radical anion and...

Université de Fribourg

Body composition-derived BMI cut-offs for overweight and obesity in Indians and Creoles of Mauritius: comparison with Caucasians

Hunma, S ; Ramuth, H ; Miles-Chan, Jennifer L. ; Schutz, Yves ; Montani, Jean-Pierre ; Joonas, N ; Dulloo, Abdul G.

In: International Journal of Obesity, 2016, vol. 40, no. 12, p. 1906–1914

Global estimates of overweight and obesity prevalence are based on the World Health Organisation (WHO) body mass index (BMI) cut-off values of 25 and 30 kg m⁻², respectively. To validate these BMI cut-offs for adiposity in the island population of Mauritius, we assessed the relationship between BMI and measured body fat mass in this population according to gender and...