In: Marine drugs, 2020, vol. 18, no. 12, p. 28
The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial counterparts, thus producing unique chemicals with a broad diversity and complexity. So far, more than 36,000 compounds have been isolated from...
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In: Journal of Neurology, 2021, no. 268, p. 817–824
Background: Data on cancer prevalence and incidence in multiple sclerosis (MS) patients are controversial. This study is aimed at estimating cancer risk in MS patients. Methods: Nested case–control study using data collected between 01/01/1987 and 28/02/2016 from the United Kingdom Clinical Practice Research Datalink. Cancer diagnoses after first MS code (index date) was counted in 10,204 MS...
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In: International journal for numerical methods in biomedical engineering, 2021, vol. 37, no. 10, p. 23
In electrocardiography, the “classic” inverse problem is the reconstruction of electric potentials at a surface enclosing the heart from remote recordings at the body surface and an accurate description of the anatomy. The latter being affected by noise and obtained with limited resolution due to clinical constraints, a possibly large uncertainty may be perpetuated in the inverse ...
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In: Endocrine, 2022, no. 75, p. 33–39
Purpose: The sensitivity of cytology after fine needle aspiration (FNA-cytology) in detecting medullary thyroid carcinoma (MTC) is low. To overcome this problem, measuring calcitonin (CT) in washout fluid of FNA (FNA-CT) has been largely diffused and showed good performance. However, no evidence-based study exists comparing systematically the sensitivity of FNA-cytology and FNA-CT. This study...
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In: Personality and individual differences, 2022, vol. 185, p. 10
The personality trait of neuroticism (N) has consistently shown to be a risk factor for Internet Addiction (IA). Review literature, however, looked at this in bivariate analyses only. To the best of our knowledge, we conducted the first review that systematically and conceptually summarized results based on the inclusion of additional factors, thus coming closer to the complex nature of the ...
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In: International journal of environmental research and public health, 2021, vol. 18, no. 19, p. 17
In order to explore the psychological impact of the COVID‐19 outbreak on the caregiver–child relationship, we investigated the interplay among COVID‐19 exposure and children’s internalizing/externalizing problems during the Italian lockdown, hypothesizing a mediation effect played by maternal distress. Additionally, we included maternal reflective functioning (i.e., hypermentalization)...
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In: Cancers, 2021, vol. 13, no. 19, p. 18
Artificial intelligence (AI) uses mathematical algorithms to perform tasks that require human cognitive abilities. AI-based methodologies, e.g., machine learning and deep learning, as well as the recently developed research field of radiomics have noticeable potential to transform medical diagnostics. AI-based techniques applied to medical imaging allow to detect biological abnormalities, to...
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In: Journal of clinical medicine, 2021, vol. 10, no. 17, p. 13
We set out to measure the health literacy (HL) of COPD patients using the Short Test of Functional Health Literacy (S- TOFHLA), perception-based screening questions (BHLS), and a specific disease knowledge test (COPD-Q). Our main focus is the relationship between functional HL and patients’ disease-knowledge, which contributes to the clarification of the relationship between the different...
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In: Cellular & molecular immunology, 2021, p. 19
Autoimmune hepatitis (AIH) is a T-cell mediated, inflammatory liver disease affecting all ages and characterized by female preponderance, elevated serum transaminase and immunoglobulin G levels, positive circulating autoantibodies, and presence of interface hepatitis at liver histology. AIH type 1, affecting both adults and children, is defined by positive anti- nuclear and/or antismooth muscle...
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In: Clinical reviews in allergy & immunology, 2021, p. 14
Circulating autoantibodies are a key diagnostic tool in autoimmune hepatitis (AIH), being positive in 95% of the cases if tested according to dedicated guidelines issued by the International Autoimmune Hepatitis Group. They also allow the distinction between type 1 AIH, characterized by positive anti-nuclear and/or anti-smooth muscle antibody, and type 2 AIH, characterized by positive...
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