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Université de Fribourg

A unilateral section of the corticospinal tract at cervical level in Primate does not lead to measurable cell loss in Motor cortex

Wannier, Thierry. ; Schmidlin, Eric ; Bloch, Jocelyne ; Rouiller, Eric M.

In: Journal of Neurotrauma, 2005, vol. 22(6), p. 703

The effects of a unilateral interruption of the dorsolateral funiculus at cervical level on the survival of neurons in the motor cortex were investigated in macaque monkeys. The lesion was made on the left side at the transition region between the 7th and 8th cervical segments, above the motoneurons controlling hand muscles. As a result, the homolateral hand became paretic,...

Université de Fribourg

Nitric oxide synthase gene transfer inhibits biological features of bypass graft disease in the human saphenous vein

Tanner, Felix C. ; Largiadèr, Thomas ; Greutert, Helen ; Yang, Zhihong ; Lüscher, Thomas F.

In: Journal of Thoracic and Cardiovascular Surgery, 2004, vol. 127, no. 1, p. 20-26

Background Bypass graft disease is related to proliferation and migration of vascular smooth muscle cells and to platelet activation with thrombus formation. Nitric oxide inhibits these biological responses; it has never been demonstrated, however, whether this occurs in intact human vascular tissue after endothelial nitric oxide synthase gene transfer. Methods We examined whether endothelial...

Université de Fribourg

Hematopoietic regulation by catecholamines

Togni, Mauro ; Dreyer, Jean-Luc (Dir.)

Thèse de doctorat : Université de Fribourg, 2000 ; no 1284.

Université de Fribourg

The tip60 HAT-complex is recruited to chromatin by the transcription factors E2F and Myc

Taubert, Stefan ; Conzelmann, Andreas (Dir.)

Thèse de doctorat : Université de Fribourg, 2003 ; no 1409.

The oncogenic transcription factors E2F and Myc bind to specific DNA sequences at distinct times during the G1 phase of the mammalian cell cycle, and regulate transcription of a plethora of target genes. E2F and Myc associate with TRRAP, a subunit of distinct macromolecular complexes that contain the histone acetyltransferases (HATs) Gcn5/PCAF or Tip60. During the course of my thesis I...

Université de Fribourg

Interaction of Per and Cry genes in the mammalian circadian clock

Oster, Henrik ; Albrecht, Urs (Dir.)

Thèse de doctorat : Université de Fribourg, 2002 ; Nr. 1396.

To cope with the daily changes in their environment, in organisms, from cyanobacteria to humans, endogenous clocks have evolved that anticipate these changes and synchronize physiology and behavior accordingly. In mammals, the central circadian pacemaker is located in the suprachiasmatic nuclei (SCN) of the hypothalamus. From there subordinated cellular clocks in the peripheral organs are...

Université de Fribourg

Automatic software configuration : a model for service provisioning in dynamic and heterogeneous environments

Schubiger-Banz, Simon ; Hisbrunner, Béat (Dir.)

Thèse de doctorat : Université de Fribourg, 2002 ; no 1393.

This dissertation addresses three fundamental problems, which have to be handled in application domains like ubiquitous computing and Web services. The three problems heterogeneity, static configuration, and dynamic configuration are not only considered to persist during the near future but to increase, as similar application domains will emerge. The heterogeneity problem is defined and examples...

Université de Fribourg

EMuds : adaptation in text-based virtual worlds

Robert, Antony ; Courant, Michèle (Dir.)

Thèse de doctorat : Université de Fribourg, 1999 ; no 1272.

Cette thèse introduit une approche méthodologique à la conception d'agents artificiels. En une tentative de résoudre le problème de l'enracinement symbolique en intelligence artificielle, une nouvelle perspective théorique sur la relation agent-environnement est explorée et un jeu d'expériences sont menées pour motiver cette méthodologie. Suite à l'idée selon laquelle l'enracinement...

Université de Fribourg

Towards active network management with "Ecomobile", an ecosystem-inspired mobile agent middleware : design, implementation, simulation and application to optical networks

Rossier-Ramuz, Daniel ; Hirsbrunner, Beat (Dir.) ; Scheurer, Rudolf (Codir.)

Thèse de doctorat : Université de Fribourg, 2002 ; no 1392.

Les futurs réseaux optiques multicouches utilisant le multiplexage en longueur d'onde permettront dans un proche avenir l'introduction de nouveaux services optiques à valeur ajoutée. Le réseau de transport passif conventionnel se transformera ainsi en une couche de transport active et intelligente. Le succès de ces nouveaux services dépendra toutefois de l'efficacité, de la résilience et...

Université de Fribourg

Optimierung automatisierter Kompaktlager in Entwurf und Steuerung

Klinkert, Andreas ; Gröflin, Heinz (Dir.) ; Liebling, Thomas M. (Codir.)

Thèse de doctorat : Université de Fribourg, 2001 ; N° 1353.

Die vorliegende Dissertation beschäftigt sich mit der Optimierung automatisierter Kompaktlager in der Phase des Entwurfs und bei der Entwicklung der Lagersteuerung. Automatisierte Kompaktlager bilden in der modernen Lagertechnik eine platzsparende Alternative zu herkömmlichen Zeilenregallagern. Ein automatisiertes Kompaktlager besteht aus mehreren Lagerebenen, welche gegliedert sind in parallel...

Université de Fribourg

The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation

Solinas, Giovanni ; Summermatter, Serge ; Mainieri, Davide ; Gubler, Marcel ; Pirola, Luciano ; Wymann, Matthias P. ; Rusconi, Sandro ; Montani, Jean-Pierre ; Seydoux, Josiane

In: FEBS Letters, 2004, vol. 577, no. 3, p. 539-544

We report here studies that integrate data of respiration rate from mouse skeletal muscle in response to leptin and pharmacological interference with intermediary metabolism, together with assays for phosphatidylinositol 3-kinase (PI3K) and AMP- activated protein kinase (AMPK). Our results suggest that the direct effect of leptin in stimulating thermogenesis in skeletal muscle is mediated by...