Thèse de doctorat : Université de Fribourg, 1999 ; no 1272.
Cette thèse introduit une approche méthodologique à la conception d'agents artificiels. En une tentative de résoudre le problème de l'enracinement symbolique en intelligence artificielle, une nouvelle perspective théorique sur la relation agent-environnement est explorée et un jeu d'expériences sont menées pour motiver cette méthodologie. Suite à l'idée selon laquelle l'enracinement...
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Thèse de doctorat : Université de Fribourg, 2002 ; no 1392.
Les futurs réseaux optiques multicouches utilisant le multiplexage en longueur d'onde permettront dans un proche avenir l'introduction de nouveaux services optiques à valeur ajoutée. Le réseau de transport passif conventionnel se transformera ainsi en une couche de transport active et intelligente. Le succès de ces nouveaux services dépendra toutefois de l'efficacité, de la résilience et...
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In: FEBS Letters, 2004, vol. 577, no. 3, p. 539-544
We report here studies that integrate data of respiration rate from mouse skeletal muscle in response to leptin and pharmacological interference with intermediary metabolism, together with assays for phosphatidylinositol 3-kinase (PI3K) and AMP- activated protein kinase (AMPK). Our results suggest that the direct effect of leptin in stimulating thermogenesis in skeletal muscle is mediated by...
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In: International Journal of Obesity, 2004, vol. 28 (Suppl. 4), p. S29-S37
Life is a combustion, but how the major fuel substrates that sustain human life compete and interact with each other for combustion has been at the epicenter of research into the pathogenesis of insulin resistance ever since Randle proposed a 'glucose-fatty acid cycle' in 1963. Since then, several features of a mutual interaction that is characterized by both reciprocality and dependency between...
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Thèse de doctorat : Università della Svizzera italiana, 2003.
Web application development still needs to employ effective methods to accommodate some distinctive aspects of the requirements analysis process: capturing high-level communication goals, considering several user profiles and stakeholders, defining hypermedia-specific requirements (concerning navigation, content, information structure and presentation aspects), and reusing requirements for an...
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In: International Journal of Obesity, 2004, vol. 28, p. S58-65
In humans and most animal models, the development of obesity leads not only to increased fat depots in classical adipose tissue locations but also to significant lipid deposits within and around other tissues and organs, a phenomenon known as ectopic fat storage. The purpose of this review is to explore the possible locations of ectopic fat in key target-organs of cardiovascular control (heart,...
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In: Circulation, 2004, vol. 110, p. 3708-3714
Background— Arginase competes with endothelial nitric oxide synthase (eNOS) for the substrate L-arginine and decreases NO production. This study investigated regulatory mechanisms of arginase activity in endothelial cells and its role in atherosclerosis. Methods and Results— In human endothelial cells isolated from umbilical veins, thrombin concentration- and time-dependently stimulated...
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In: Tissue and Cell, 2004, vol. 36, no. 4, p. 249-252
In the present investigation the sole plate area of motor end plates of the frog is ultrastructurally examined with different postfixation methods. We concentrated in this case on the proof of the smooth and rough sarcoplasmic reticulum of the sole plate. The relations of the smooth and rough sarcoplasmic reticulum to subsynaptic folds and the local T-system and its connections to diads and...
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In: Brain Research, 2004, vol. 1017, p. 172-182
After a sub-total hemisection of the cervical cord at level C7/C8 in monkeys, a paralysis of the homolateral hand is rapidly followed by an incomplete recovery of manual dexterity, reaching a plateau after about 40–50 days, whose extent appears related to the size of the lesion. During a few days after the lesion, the hand representation in the contralateral motor cortex disappeared, replaced...
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In: Audiology and Neuro-Otology, 2004, vol. 9, p. 144-159
To investigate neural adaptive properties, near-field evoked potentials were recorded from a chronically implanted electrode in the ventral cochlear nucleus in awake Long-Evans rats exposed to acoustic stimuli or receiving intracochlear electric stimulation. Stimuli were 250-ms trains of repetitive acoustic clicks (10, 30 and 50 dB SPL) or biphasic electric pulses (30, 50 and 70 µA) with...
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