In: Annual Review of Immunology
P. falciparum remains a serious public health problem and a continuous challenge for the immune system due to the complexity and diversity of the pathogen. Recent advances from several laboratories in the characterization of the antibody response to the parasite have led to the identification of critical targets for protection and revealed a new mechanism of diversification based on the...
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An efficient fork/join application should maximize parallelism while minimizing overheads, and maximize locality while minimizing contention. However, there is no unique optimal implementation that best resolves such tradeoffs and failing in balancing them may lead to fork/join applications suffering from several issues (e.g., suboptimal forking, load imbalance, excessive synchronization),...
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We investigate the relationship between costs and quality in nonprofit nursing homes, a key issue in the present context of cost containment measures. In accordance with the economic theory of production, we estimate a three-inputs total cost function for nursing home services using data from 45 nursing homes in Switzerland between 2006 and 2010. Quality is measured by means of clinical...
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We describe an empirical evaluation of a visualization approach based on a 3D city metaphor, implemented in a tool called CodeCity. We designed the controlled experiment based on a set of lessons extracted from the current body of research and perfected it during a preliminary pilot phase. We then conducted the experiment in four locations across three countries over a period of four months,...
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Partial replication is a way to increase the scalability of replicated systems since updates only need to be applied to a subset of the system’s sites, thus allowing replicas to handle independent parts of the workload in parallel. In this paper, we propose P-Store, a partial database replication protocol for wide area networks. In P-Store, each transaction T optimistically executes on one...
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In this paper we study the ability of convergent subdivision schemes to reproduce polynomials in the sense that for initial data, which is sampled from some polynomial function, the scheme yields the same polynomial in the limit. This property is desirable because the reproduction of polynomials up to some degree d implies that a scheme has approximation order d + 1. We first show that any...
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We present an ontology-driven approach to semantic annotation, indexing and retrieval of document units. This approach is based on a novel semantic document model (SDM) that we developed to make office-like document units be uniquely identified, semantically annotated with concepts from annotation ontologies and linkable across document boundaries. In the semantic annotation model that we...
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Middleware for Web service compositions, such as BPEL engines, provides the execution environment for services as well as additional functionalities, such as monitoring and self-tuning. Given its role in service provisioning, it is very important to assess the performance of middleware in the context of a Service-oriented Architecture (SOA). This paper presents SOABench, a framework for the...
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We address the problem that existing publish/subscribe messaging systems, including such commonly used ones as Apache’s ActiveMQ and IBM’s WebSphere MQ, exhibit degraded end-to-end throughput performance in a wide-area network setting. We contend that the cause of this problem is the lack of an appropriate routing protocol. Building on the idea of a content-based network, we introduce a...
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We defined the notion of property templates after we observed that many system failures can be clustered according to their symptoms, and the design constraints these failures violate [PW09]. In this technical report we document the semantics of property templates, and how we implemented these semantics in AspectJ code templates that support assertion generation for Java programs.
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