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Université de Neuchâtel

Measurements of grammaticalization : developing a quantitative index for the study of grammatical change

Correia Saavedra, David ; Hilpert, Martin (Dir.) ; Petré, Peter (Codir.) ; Smirnova, Elena (Codir.) ; Smet, Hendrik de (Codir.) ; Hundt, Marianne (Codir.)

Thèse de doctorat : Université de Neuchâtel, 2019.

There is a broad consensus that grammaticalization is a process that is gradual and largely unidirectional: lexical elements acquire grammatical functions, and grammatical elements can undergo further grammaticalization (Hopper and Traugott 2003). This consensus is based on substantial cross-linguistic evidence. While most existing studies present qualitative evidence, this dissertation discusses...

Université de Fribourg

Changer le travail ou changer la société ? : Les hackers entre conformation à l'ordre social et volonté d'innover

Zufferey, Eric ; Surdez, Muriel (Dir.)

Thèse de doctorat : Université de Fribourg, 2018.

Changing workplace or society? Hackers between compliance with the social order and the will to innovate. This thesis looks at hacking as source of social change, or even subversion of the social order. Hacking involves self-directed learning and remove social barriers between hobbyists, professionals and activists. Therefore, it raises the hope to renew the access to knowledge and the role of...

Università della Svizzera italiana

Enhancing multi-scale cardiac simulations by coupling electrophysiology and mechanics : a flexible high performance approach to cardiac electromechanics

Pozzi, Sonia ; Krause, Rolf (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2019 ; 2019INFO005.

This work focuses on the development of computational methods for the simulation of the propagation of the electrical potential in the heart and of the resulting mechanical contraction. The interaction of these two physical phenomena is described by an electromechanical model which consists of the monodomain system, which describes the propagation of the action potential in the cardiac tissue,...

Università della Svizzera italiana

Monetary policy and interest rate products

Zurowski, Wojciech ; Schneider, Paul (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2019 ; 20019ECO002.

My PhD thesis consists of three papers which study how interest rate products' prices react to both the central bank's policy goals and communication. As tool I make use of various econometric techniques such as affine models, general method of moments or Haar like filtering. The first chapter studies government bond excess term premia. I show that their predictability is driven by monetary...

Université de Neuchâtel

Groundwater recharge dynamics by snowmelt

Meeks, Jessica ; Hunkeler, Daniel (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2018.

Understanding the recharge mechanisms for karst aquifers is of great importance because these aquifers are relied upon by a quarter of Earth’s population, and because their recharge and discharge dynamics are often strongly coupled. Given this coupling, karst groundwater resources are inherently susceptible to surface processes such as climate, where the timing and volume of water infiltration...

Université de Neuchâtel

Increasing the size of metalla-assemblies to target the EPR-effect of tumors and solid cancers

Mannancherril, Vidya ; Therrien, Bruno (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2019.

Cancer, a malignant disease, is one of the leading causes of mortality and morbidity among humans. However, selective targeting of cancerous tissue remains challenging. The enhanced permeability and retention effect (EPR-effect), a naturally occurring phenomenon in solid cancerous tissue, is a suitable treatment pathway to selectively target cancerous tissues, whereas healthy tissue remains...

Université de Neuchâtel

Handling auxiliary variables in survey sampling and nonresponse

Vallée, Audrey-Anne ; Tillé, Yves (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2019.

This manuscript is dedicated to the use of auxiliary information in survey sampling and nonresponse. We are interested in the integration of auxiliary variables in sampling methods and in the treatment of nonresponse to improve the efficiency and the precision of surveys. We also deal with the calculation of the precision of estimators. Indeed, variances rapidly become difficult to calculate when...

Université de Neuchâtel

Semantic content in titi monkey alarm call sequences

Berthet, Mélissa ; Zuberbühler, Klaus (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2018.

The comparative approach aims to understand the uniqueness of human language and how it evolved from primitive communication systems. Black-fronted titi monkeys Callicebus nigrifrons possess two soft alarm calls: A-calls are specific to threats within the canopy while B-calls are general calls emitted to terrestrial predators but also in non-predatory contexts, while moving near the...

Université de Fribourg

Stress und seine Bedeutung in der Kindheit : die Messung von frühen Stressoren und möglichen Folgen auf die psychische Gesundheit von Vorschulkindern

Stülb, Kerstin ; Munsch, Simone (Dir.)

Thèse de doctorat : Université de Fribourg, 2018.

Early adversities such as critical live events or cumulative everyday challenges might exceed individual coping strategies or resources and thus lead to pathological changes in the long term. Maladaptive physiological and psychological processes as a consequence of dysfunctional stress response are the basis of these changes. Preschool age plays an important role in this context, since the...

Università della Svizzera italiana

Deciphering the complexity of human noncoding promoter-proximal transcriptome : different scales of transcriptional control : from a single gene to the whole epigenome

Mapelli, Sarah Natalia ; Krause, Rolf (Dir.) ; Catapano, Carlo V. (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2019 ; 2019INFO001.

Long noncoding RNAs (lncRNAs) have gained increasing interest in molecular studies, their active participation in important biological functions has emerged and their direct involvement in genomic reprogramming during development and diseases, including cancer, has been demonstrated. Several studies have shown their active contribution in transcriptional control and they are emerging as...