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Accès public à partir du 30 janv. 2020
Università della Svizzera italiana

The contribution of active and passive mechanisms of 5mC and 5hmC removal in human T lymphocytes is differentiation- and activation-dependent

Vincenzetti, Lucia ; Leoni, Cristina ; Chirichella, Michele ; Kwee, Ivo ; Monticelli, Silvia

In: European Journal of Immunology, 2019, p. 1-15

In mammals, the 5’-methylcytosine (5mC) modification in the genomic DNA contributes to the dynamic control of gene expression. 5mC erasure is required for the activation of developmental programs and occurs either by passive dilution through DNA replication, or by enzymatic oxidation of the methyl mark to 5-hydroxymethylcytosine (5hmC), which can persist as such or undergo further oxidation...

Università della Svizzera italiana

A selective ER‐phagy exerts procollagen quality control via a Calnexin‐FAM134B complex

Forrester, Alison ; Leonibus, Chiara De ; Grumati, Paolo ; Fasana, Elisa ; Piemontese, Marilina ; Staiano, Leopoldo ; Fregno, Ilaria ; Raimondi, Andrea ; Marazza, Alessandro ; Bruno, Gemma ; Iavazzo, Maria ; Intartaglia, Daniela ; Seczynska, Marta ; van Anken, Eelco ; Conte, Ivan ; De Matteis, Maria Antonietta ; Dikic, Ivan ; Molinari, Maurizio ; Settembre, Carmine

In: The EMBO Journal, 2019, vol. 38, no. 2, p. e99847

Autophagy is a cytosolic quality control process that recognizes substrates through receptor‐mediated mechanisms. Procollagens, the most abundant gene products in Metazoa, are synthesized in the endoplasmic reticulum (ER), and a fraction that fails to attain the native structure is cleared by autophagy. However, how autophagy selectively recognizes misfolded procollagens in the ER lumen is...

Università della Svizzera italiana

ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens

Proietti, Michele ; Perruzza, Lisa ; Scribano, Daniela ; Pellegrini, Giovanni ; D’Antuono, Rocco ; Strati, Francesco ; Raffaelli, Marco ; Gonzalez, Santiago F. ; Thelen, Marcus ; Hardt, Wolf-Dietrich ; Slack, Emma ; Nicoletti, Mauro ; Grassi, Fabio

In: Nature Communications, 2019, vol. 10, p. Art. number: 250

T cell dependent secretory IgA (SIgA) generated in the Peyer’s patches (PPs) of the small intestine shapes a broadly diverse microbiota that is crucial for host physiology. The mutualistic co-evolution of host and microbes led to the relative tolerance of host’s immune system towards commensal microorganisms. The ATP-gated ionotropic P2X7 receptor limits T follicular helper (Tfh) cells...

Université de Fribourg

A test of positive suggestions about side effects as a way of enhancing the analgesic response to NSAIDs

Fernandez, Aurore ; Kirsch, Irving ; Noël, Louis ; Rodondi, Pierre Yves ; Kaptchuk, Ted J. ; Suter, Marc R. ; Décosterd, Isabelle ; Berna, Chantal

In: PLOS ONE, 2019, vol. 14, no. 1, p. e0209851

Side effects are frequent in pharmacological pain management, potentially preceding analgesia and limiting drug tolerability. Discussing side effects is part of informed consent, yet can favor nocebo effects. This study aimed to test whether a positive suggestion regarding side effects, which could act as reminders of the medication having been absorbed, might favor analgesia in a clinical...

Università della Svizzera italiana

P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus

Faliti, Caterina E. ; Gualtierotti, Roberta ; Rottoli, Elsa ; Gerosa, Maria ; Perruzza, Lisa ; Romagnani, Andrea ; Pellegrini, Giovanni ; De Ponte Conti, Benedetta ; Rossi, Riccardo L. ; Idzko, Marco ; Mazza, Emilia M.C. ; Bicciato, Silvio ; Traggiai, Elisabetta ; Meroni, Pier Luigi ; Grassi, Fabio ; Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi,” Milan, Italy

In: Journal of Experimental Medicine, 2019, vol. 216, no. 2, p. 317-336

Altered control of T follicular helper (Tfh) cells can lead to generation of autoantibodies and autoimmune manifestations. Signaling pathways that selectively limit pathogenic responses without affecting the protective function of Tfh cells are unknown. Here we show that the ATP-gated ionotropic P2X7 receptor restricts the expansion of aberrant Tfh cells and the generation of self-reactive...

Haute Ecole de Gestion & Tourisme

User-oriented intuitive web interface for SanTour

Lerto, Mikko ; Cotting, Alexandre (Dir.)

Mémoire de bachelor : Haute Ecole de Gestion & Tourisme, 2018.

The purpose of this research is to create an intuitive user-interface for a hiking application while considering the needs of people with physical and mental limitations. SanTour is a hiking application designed for people with physical or mental limitations. These limitations can for example be the fear of heights or reduced mobility in the knees. The latest version of SanTour at the time of...

Haute Ecole de Gestion & Tourisme

Analysis, design, and implementation of an infrastructure-less situation awareness application

Bonvin, Flavien ; Bocchi, Yann (Dir.)

Mémoire de bachelor : Haute Ecole de Gestion & Tourisme, 2018.

This work aims to implement an application based on opportunistic communication. It must be operational in a disaster situation when the cellular network is not available. During this work, a first part was consecrated to the study of the several types of ad hoc networks and the various technologies related to them. This has served as a foundation for the study of ad hoc networks in...

Université de Neuchâtel

On reducing latency in geo-distributed systems through state partitioning and caching

Halalai, Raluca ; Felber, Pascal (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2018.

Les systèmes distribués modernes sont de plus en plus grands, et sont déployés dans plusieurs régions géographiques. L’objectif final de tels systèmes est de fournir des services à leurs utilisateurs ainsi que haute disponibilité et bonne performance. Cette thèse propose des techniques pour réduire le latence perçue par des utilisateurs. Pour commencer, nous...

Université de Fribourg

A detailed review on the clinical anatomy of the pectoralis major muscle

Larionov, Alexey ; Yotovski, Peter ; Filgueira, Luis

In: SM Journal of Clinical Anatomy, 2018, vol. 2, no. 3, p. 1015

The pectoralis major is a muscle of the upper limb girdle. This muscle has a unique morphological architectonic and a high rate of clinical applications. However, there is lack of data regarding the morphological and functional interactions of the pectoralis major with other muscle and fascial compartments. According to the applied knowledge, the “Humero-pectoral” morpho-functional...

Université de Fribourg

Enhancing scientific communication skills: a real-world simulation in a tertiary-level life science class using e-learning technology in biomedical literature perception, reflective review writing on a clinical issue, and self and peer assessments

Eppler, Elisabeth ; Meyer, Jan ; Serowy, Steffen ; Link, Karl ; Pauk, Barbara ; Filgueira, Luis

In: Research in Science Education, 2018, p. -

This educational study aimed to explore the feasibility and acceptance of a literacy exercise adopted from the realworld of scientific publishing in a cell and tissue biology course. For that purpose, a tertiary-level multimodality science course, which integrated a blended learning faculty and student lectures, journal club, and wet laboratory sessions including a research project as well as...