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Université de Fribourg

Induction of myocardial infarction in adult zebrafish using cryoinjury

Chablais, Fabian ; Jaźwińska, Anna

In: Journal of Visual Experiments, 2012, vol. 62, p. e3666

The mammalian heart is incapable of significant regeneration following an acute injury such as myocardial infarction. By contrast, urodele amphibians and teleost fish retain a remarkable capacity for cardiac regeneration with little or no scarring throughout life. It is not known why only some non-mammalian vertebrates can recreate a complete organ from remnant tissues. To understand the...

Université de Fribourg

Rapid turnover of the “functional” Na⁺–Ca²⁺ exchanger in cardiac myocytes revealed by an antisense oligodeoxynucleotide approach

Egger, Marcel ; Porzig, Hartmut ; Niggli, Ernst ; Schwaller, Beat

In: Cell Calcium, 2005, vol. 37, no. 3, p. 233-243

Antisense oligodeoxynucleotides (AS-ODNs) were used in combination with transient functional expression of the cardiac Na⁺–Ca²⁺ exchanger (NCX1) to correlate suppression of the Na⁺–Ca²⁺ exchange function with down-regulation of NCX1 protein expression. In a de-novo expression system (Sf9 cells), a decrease in both, NCX1 mRNA and protein after AS-ODN application was paralleled by...