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Université de Fribourg

Acute endotoxemia in mice induces downregulation of megalin and cubilin in the kidney

Schreiber, Andrea ; Theilig, Franziska ; Schweda, Frank ; Höcherl, Klaus

In: Kidney International, 2012, p. -

Severe sepsis is often accompanied by acute renal failure with renal tubular dysfunction. Albuminuria is a common finding in septic patients and we studied whether it was due to an impairment of proximal tubular endocytosis of filtered albumin. We studied the regulation of megalin and cubilin, the two critical multiligand receptors responsible for albumin absorption, during severe experimental...