Università della Svizzera italiana

miR-146a and NF-κB1 regulate mast cell survival and T lymphocyte differentiation

Rusca, Nicole ; Dehò, Lorenzo ; Montagner, Sara ; Zielinski, Christina E. ; Sica, Antonio ; Sallusto, Federica ; Monticelli, Silvia

In: Molecular and cellular biology, 2012, vol. 32, no. 21, p. 4432-4444

The transcription factor NF-κB regulates the expression of a broad number of genes central to immune and inflammatory responses. We identified a new molecular network that comprises specifically the NF-κB family member NF-κB1 (p50) and miR-146a, and we show that in mast cells it contributes to the regulation of cell homeostasis and survival, while in T lymphocytes it modulates T cell...

Università della Svizzera italiana

Dnmt3a restrains mast cell inflammatory responses

Leoni, Cristina ; Montagner, Sara ; Rinaldi, Andrea ; Bertoni, Francesco ; Polletti, Sara ; Balestrieri, Chiara ; Monticelli, Silvia

In: Proceedings of the national academy of sciences, 2017, vol. 114, no. 8, p. E1490-E1499

DNA methylation and specifically the DNA methyltransferase enzyme DNMT3A are involved in the pathogenesis of a variety of hematological diseases and in regulating the function of immune cells. Although altered DNA methylation patterns and mutations in DNMT3A correlate with mast cell proliferative disorders in humans, the role of DNA methylation in mast cell biology is not understood. By using...

Consortium of Swiss Academic Libraries

Human Mast Cells and Mastocytosis: Harnessing MicroRNA Expression as a New Approach to Therapy?

Deho', Lorenzo ; Monticelli, Silvia

In: Archivum Immunologiae et Therapiae Experimentalis, 2010, vol. 58, no. 4, p. 279-286