In: British Journal of Nutrition, 2011, vol. 105, no. 12, p. 1750-1763
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In: Cahiers de Nutrition et de Diététique, 2013, vol. 48, no. 1, p. 15–25
Le titre d’un livre publié en 1983 ‘Dieting Makes You Fat’ – concrétise la notion que faire un régime pour contrôler son poids, et par conséquent l’effet yo-yo, prédispose l’individu à être encore plus gras. Alors que cette notion est controversée, son débat souligne le fossé qui existe dans notre compréhension des lois fondamentales de la physiologie qui gouvernent la...
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In: International Journal of Obesity, 2006, vol. 30, no. S4, p. S23–S35
The analyses of large epidemiological databases have suggested that infants and children who show catch-up growth, or adiposity rebound at a younger age, are predisposed to the development of obesity, type 2 diabetes and cardiovascular diseases later in life. The pathophysiological mechanisms by which these growth trajectories confer increased risks for these diseases are obscure, but there is...
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In: The FASEB Journal, 2006, vol. 20, no. 10, p. 1751-1753
An enhanced metabolic efficiency for accelerating the recovery of fat mass (or catch-up fat) is a characteristic feature of body weight regulation after weight loss or growth retardation and is the outcome of an "adipose-specific" suppression of thermogenesis, i.e., a feedback control system in which signals from the depleted adipose tissue fat stores exert a suppressive effect on thermogenesis....
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In: Endocrinology, 2006, vol. 147(1), p. 31-38
The mechanisms by which CRH and related peptides (i.e. the CRH/urocortin system) exert their control over thermogenesis and weight regulation have until now focused only upon their effects on brain centers controlling sympathetic outflow. Using a method that involves repeated oxygen uptake determinations in intact mouse skeletal muscle, we report here that CRH can act directly on skeletal...
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In: FEBS Letters, 2004, vol. 577, no. 3, p. 539-544
We report here studies that integrate data of respiration rate from mouse skeletal muscle in response to leptin and pharmacological interference with intermediary metabolism, together with assays for phosphatidylinositol 3-kinase (PI3K) and AMP- activated protein kinase (AMPK). Our results suggest that the direct effect of leptin in stimulating thermogenesis in skeletal muscle is mediated by...
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In: International Journal of Obesity, 2004, vol. 28 (Suppl. 4), p. S29-S37
Life is a combustion, but how the major fuel substrates that sustain human life compete and interact with each other for combustion has been at the epicenter of research into the pathogenesis of insulin resistance ever since Randle proposed a 'glucose-fatty acid cycle' in 1963. Since then, several features of a mutual interaction that is characterized by both reciprocality and dependency between...
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In: Physiology & Behavior, 2004, vol. 83, no. 4, p. 587-602
After decades of controversies about the quantitative importance of autoregulatory adjustments in energy expenditure in weight regulation, there is now increasing recognition that even subtle variations in thermogenesis could, in dynamic systems and over the long term, be important in determining weight maintenance in some and obesity in others. The main challenge nowadays is to provide a...
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