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Proteome-wide analysis of HIV-specific naive and memory CD4+ T cells in unexposed blood donors

Campion, Suzanne L. ; Brodie, Tess M. ; Fischer, William ; Korber, Bette T. ; Rossetti, Astrea ; Goonetilleke, Nilu ; McMichael, Andrew J. ; Sallusto, Federica

In: Journal of experimental medicine, 2014, vol. 211, no. 7, p. 1273-1280

The preexisting HIV-1–specific T cell repertoire must influence both the immunodominance of T cells after infection and immunogenicity of vaccines. We directly compared two methods for measuring the preexisting CD4+ T cell repertoire in healthy HIV-1–negative volunteers, the HLA-peptide tetramer enrichment and T cell library technique, and show high concordance (r = 0.989). Using the...