Université de Fribourg

Can the Ames test provide an insight into nano-object mutagenicity? Investigating the interaction between nano-objects and bacteria

Clift, Martin J. D. ; Raemy, David O. ; Endes, Carola ; Ali, Zulqurnain ; Lehmann, Andrea D. ; Brandenberger, Christina ; Petri-Fink, Alke ; Wick, Peter ; Parak, Wolfgang J. ; Gehr, Peter ; Schins, Roel P. F. ; Rothen-Rutishauser, Barbara

In: Nanotoxicology, 2013, vol. 7, no. 8, p. 1373–1385

The aim of this study was to assess the interaction of a series of well characterised nano-objects with the Gram negative bacterium Salmonella typhimurium, and how such an interaction may relate to the potential mutagenicity of nano-objects. Transmission electron microscopy showed that nano-objects (Au-PMA-ATTO NPs, CeO₂ NPs, SWCNTs and MWCNTs), as well as CAFs entered S....