Université de Fribourg

An in vitro testing strategy towards mimicking the inhalation of high aspect ratio nanoparticles

Endes, Carola ; Schmid, Otmar ; Kinnear, Calum ; Mueller, Silvana ; Camarero-Espinosa, Sandra ; Vanhecke, Dimitri ; Foster, E. Johan ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Weder, Christoph ; Clift, Martin J.D.

In: Particle and Fibre Toxicology, 2015, vol. 11, no. 1, p. 40

The challenge remains to reliably mimic human exposure to high aspect ratio nanoparticles (HARN) via inhalation. Sophisticated, multi-cellular in vitro models are a particular advantageous solution to this issue, especially when considering the need to provide realistic and efficient alternatives to invasive animal experimentation for HARN hazard assessment. By incorporating a systematic test-bed...