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Assessing the impact of the physical properties of industrially produced carbon nanotubes on their interaction with human primary macrophages in vitro

Clift, Martin J.D. ; Frey, Sabine ; Endes, Carola ; Hirsch, Vera ; Kuhn, Dagmar A. ; Johnston, Blair D. ; Wick, Peter ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: BioNanoMaterials, 2013, vol. 14, no. 3-4, p. 239-248

Nanoparticle colloidal stability in cell culture media and impact on cellular interactions

Moore, Thomas L. ; Rodriguez-Lorenzo, Laura ; Hirsch, Vera ; Balog, Sandor ; Urban, Dominic ; Jud, Corinne ; Rothen-Rutishauser, Barbara ; Lattuada, Marco ; Petri-Fink, Alke

In: Chemical Society Reviews, 2015, vol. 44, no. 17, p. 6287–6305

Nanomaterials are finding increasing use for biomedical applications such as imaging, diagnostics, and drug delivery. While it is well understood that nanoparticle (NP) physico-chemical properties can dictate biological responses and interactions, it has been difficult to outline a unifying framework to directly link NP properties to expected in vitro and in vivo outcomes. When introduced to...

In Vitro dosimetry of agglomerates

Hirsch, Vera ; Kinnear, Calum ; Rodriguez-Lorenzo, Laura ; Monnier, Christophe A. ; Rothen-Rutishauser, Barbara ; Balog, Sandor ; Petri-Fink, Alke

In: Nanoscale, 2014, p. -

Agglomeration of nanoparticles in biological fluids is a pervasive phenomenon that leads to difficulty in the interpretation of results from in vitro exposures, primarily due to the differing particokinetics of agglomerates to nanoparticles. Therefore, well-defined small agglomerates were designed that possessed different particokinetics profiles, and their cellular uptake was compared to a...

Surface charge of polymer coated SPIONs influences the serum protein adsorption, colloidal stability and subsequent cell interaction in vitro

Hirsch, Vera ; Kinnear, Calum ; Moniatte, Marc ; Rothen-Rutishauser, Barbara ; Clift, Martin J. D. ; Fink, Alke

In: Nanoscale, 2013, vol. 5, no. 9, p. 3723-3732

It is known that the nanoparticle–cell interaction strongly depends on the physicochemical properties of the investigated particles. In addition, medium density and viscosity influence the colloidal behaviour of nanoparticles. Here, we show how nanoparticle–protein interactions are related to the particular physicochemical characteristics of the particles, such as their colloidal stability,...

Influence of serum supplemented cell culture medium on colloidal stability of polymer coated iron oxide and polystyrene nanoparticles with impact on cell interactions in vitro

Hirsch, Vera ; Salaklang, Jatuporn ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: IEEE Transactions on Magnetics, 2012, vol. 49, no. 1, p. 402-407

When nanoparticles interact with cells, the possible cellular responses to the particles depend on an array of parameters, in both particle and biological aspects. On the one hand, the physicochemical properties of the particles (e.g., material, size, shape, and surface charge) are known to play a key role in particle-cell interactions. On the other hand, it has been shown that prior to coming...