Perfeziona i miei risultati

Advanced human in vitro models to assess metal oxide nanoparticle-cell interactions

Wick, Peter ; Grafmueller, Stefanie ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: MRS Bulletin, 2014, vol. 39, no. 11, p. 984-989

Assessing the impact of the physical properties of industrially produced carbon nanotubes on their interaction with human primary macrophages in vitro

Clift, Martin J.D. ; Frey, Sabine ; Endes, Carola ; Hirsch, Vera ; Kuhn, Dagmar A. ; Johnston, Blair D. ; Wick, Peter ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: BioNanoMaterials, 2013, vol. 14, no. 3-4, p. 239-248

Can the Ames test provide an insight into nano-object mutagenicity? Investigating the interaction between nano-objects and bacteria

Clift, Martin J. D. ; Raemy, David O. ; Endes, Carola ; Ali, Zulqurnain ; Lehmann, Andrea D. ; Brandenberger, Christina ; Petri-Fink, Alke ; Wick, Peter ; Parak, Wolfgang J. ; Gehr, Peter ; Schins, Roel P. F. ; Rothen-Rutishauser, Barbara

In: Nanotoxicology, 2013, vol. 7, no. 8, p. 1373–1385

The aim of this study was to assess the interaction of a series of well characterised nano-objects with the Gram negative bacterium Salmonella typhimurium, and how such an interaction may relate to the potential mutagenicity of nano-objects. Transmission electron microscopy showed that nano-objects (Au-PMA-ATTO NPs, CeO₂ NPs, SWCNTs and MWCNTs), as well as CAFs entered S....

A Comparative Study of Different In Vitro Lung Cell Culture Systems to Assess the Most Beneficial Tool for Screening the Potential Adverse Effects of Carbon Nanotubes

Clift, Martin J. D. ; Endes, Carola ; Vanhecke, Dimitri ; Wick, Peter ; Gehr, Peter ; Schins, Roel P. F. ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Toxicological Sciences, 2014, vol. 137, no. 1, p. 55-64

A comparative study of different in vitro lung cell culture systems to assess the most beneficial tool for screening the potential adverse effects of carbon nanotubes

Clift, Martin J. D. ; Endes, Carola ; Vanhecke, Dimitri ; Wick, Peter ; Gehr, Peter ; Schins, Roel P. F. ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Toxicological Sciences, 2014, vol. 137, no. 1, p. 55-64

To determine the potential inhalatory risk posed by carbon nanotubes (CNTs), a tier-based approach beginning with an in vitro assessment must be adopted. The purpose of this study therefore was to compare 4 commonly used in vitro systems of the human lung (human blood monocyte-derived macrophages [MDM] and monocyte-derived dendritic cells [MDDC], 16HBE14o- epithelial cells, and...

Editorial by the guest editors : Special Issue: NANOSAFETY - Progress in (eco)toxicology, understanding of mechanisms of action and risk assessment towards a reliable and sustainable use of nanotechnology

Wick, Peter ; Dini, Luciana ; Kuhlbusch, Thomas

In: BioNanoMaterials, 2013, vol. 14, no. 1-2, p. 3-3

Effect of particle agglomeration in nanotoxicology

Bruinink, Arie ; Wang, Jing ; Wick, Peter

In: Archives of Toxicology, 2015, vol. 89, no. 5, p. 659-675

Human asthmatic bronchial cells are more susceptible to subchronic repeated exposures of aerosolized carbon nanotubes at occupationally relevant doses than healthy cells

Chortarea, Savvina ; Barosova, Hana ; Clift, Martin James David ; Wick, Peter ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: ACS Nano, 2017, p. -

Although acute pulmonary toxicity of carbon nanotubes (CNTs) has been extensively investigated, the knowledge of potential health effects following chronic occupational exposure is currently limited and based only upon in vivo approaches. Our aim was to realistically mimic subchronic inhalation of multiwalled CNTs (MWCNTs) in vitro, using the air–liquid interface cell exposure (ALICE)...

Human epithelial cells in vitro – Are they an advantageous tool to help understand the nanomaterial-biological barrier interaction?

Rothen-Rutishauser, Barbara ; Clift, Martin J.D. ; Jud, Corinne ; Fink, Alke ; Wick, Peter

In: Euro Nanotox Letters, 2012, vol. 4, no. 01, p. 1-20

The human body can be exposed to nanomaterials through a variety of different routes. As nanomaterials get in contact with the skin, the gastrointestinal tract, and the respiratory tract, these biological compartments are acting as barriers to the passage of nano-sized materials into the organism. These structural and functional barriers are provided by the epithelia serving as an interface...

Intracellular vesicle transport in "Arabidopsis thaliana" : functional characterization of the t-SNARE homologue AtSNAP33

Wick, Peter ; Sticher, Liliane (Dir.)

Thèse de doctorat : Université de Fribourg, 2002 ; no 1386.

The secretory pathway is a complex endomembrane system essential for all eukaryotic cells. It transports proteins to the extracellular space or to the vacuole. All proteins which are secreted are synthesized at the endoplasmic reticulum (ER) and have a signal peptide in common. The signal peptide is necessary for the transport into the lumen of the ER where the correct folding of the protein...