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Université de Fribourg

Quantification of gold nanoparticle cell uptake under controlled biological conditions and adequate resolution

Rothen-Rutishauser, Barbara ; Kuhn, Dagmar A ; Ali, Zulqurnain ; Gasser, Michael ; Amin, Faheem ; Parak, Wolfgang J ; Vanhecke, Dimitri ; Fink, Alke ; Gehr, Peter ; Brandenberger, Christina

In: Nanomedicine, 2014, vol. 9, no. 5, p. 607–621

Aim: We examined cellular uptake mechanisms of fluorescently labeled polymer-coated gold nanoparticles (NPs) under different biological conditions by two quantitative, microscopic approaches. Materials & methods: Uptake mechanisms were evaluated using endocytotic inhibitors that were tested for specificity and cytotoxicity. Cellular uptake of gold NPs was analyzed either by laser scanning...

Université de Fribourg

Multi-functional magnetic photoluminescent photocatalytic polystyrene-based micro- and nano-fibers Obtained by electrospinning

Schaer, Michel ; Crittin, Mireille ; Kasmi, Lamia ; Pierzchala, Katarzyna ; Calderone, Caroline ; Digigow, Reinaldo G. ; Fink, Alke ; Forró, László ; Sienkiewicz, Andrzej

In: Fibers, 2014, vol. 2, no. 1, p. 75–91

This work reports on the implementation of electrospinning (ES) as a facile route to encapsulate nano-engineered materials in a polystyrene (PS) matrix. We applied ES to co-encapsulate two kinds of nanoparticles, i.e., upconversion nanophosphors (UCNPs) and superparamagnetic iron oxide nanoparticles (SPIONs), in polystyrene (PS)-based micro- and nano-fibers (PSFs). This approach made it...

Université de Fribourg

Comparison of the toxicity of diesel exhaust produced by bio- and fossil diesel combustion in human lung cells in vitro

Steiner, Sandro ; Czerwinski, Jan ; Comte, Pierre ; Popovicheva, Olga ; Kireeva, Elena ; Müller, Loretta ; Heeb, Norbert ; Mayer, Andreas ; Fink, Alke ; Rothen-Rutishauser, Barbara

In: Atmospheric Environment, 2013, vol. 81, p. 380–388

Alternative fuels are increasingly combusted in diesel- and gasoline engines and the contribution of such exhausts to the overall air pollution is on the rise. Recent findings on the possible adverse effects of biodiesel exhaust are contradictive, at least partly resulting from the various fuel qualities, engine types and different operation conditions that were tested. However, most of the...

Université de Fribourg

Non-Scanning magnetic field imaging with laser-pumped atomic magnetometer

Lebedev, Victor ; Dolgovskiy, V. ; Michen, B. ; Fink, Alke ; Bison, Georg ; Weis, Antoine

In: Biomedical Engineering / Biomedizinische Technik, 2013, p. -

We present first results on the imaging of the two dimensional magnetic field distributions using a recently developed magnetic field imaging camera (MFIC). The instrument is based on laser-pumped atomic magnetometry with an alkali vapour in a buffer gas. The device provides millimetre spatial and sub-second time resolution, and allows mapping the magnetic field from circa 2 cm2...

Université de Fribourg

Bis-TEGylated poly(p-benzamide)s: combining organosolubility with shape persistence

Schulze, Maren ; Michen, Benjamin ; Fink, Alke ; Kilbinger, and Andreas F. M.

In: Macromolecules, 2013, vol. 46, no. 14, p. 5520–5530

The synthesis of perfectly planar, bis-substituted aromatic polyamides is reported herein. With highly flexible triethylene glycol chains attached and conformational restriction through intramolecular, bifurcated hydrogen bonds these are among the most shape-persistent yet organo-soluble polymers to date. Starting from 4-nitrosalicylic acid, our group developed a route to phenyl-2,5-bis-TEGylated...

Université de Fribourg

Surface charge of polymer coated SPIONs influences the serum protein adsorption, colloidal stability and subsequent cell interaction in vitro

Hirsch, Vera ; Kinnear, Calum ; Moniatte, Marc ; Rothen-Rutishauser, Barbara ; Clift, Martin J. D. ; Fink, Alke

In: Nanoscale, 2013, vol. 5, no. 9, p. 3723-3732

It is known that the nanoparticle–cell interaction strongly depends on the physicochemical properties of the investigated particles. In addition, medium density and viscosity influence the colloidal behaviour of nanoparticles. Here, we show how nanoparticle–protein interactions are related to the particular physicochemical characteristics of the particles, such as their colloidal stability,...

Université de Fribourg

Human epithelial cells in vitro – Are they an advantageous tool to help understand the nanomaterial-biological barrier interaction?

Rothen-Rutishauser, Barbara ; Clift, Martin J.D. ; Jud, Corinne ; Fink, Alke ; Wick, Peter

In: Euro Nanotox Letters, 2012, vol. 4, no. 01, p. 1-20

The human body can be exposed to nanomaterials through a variety of different routes. As nanomaterials get in contact with the skin, the gastrointestinal tract, and the respiratory tract, these biological compartments are acting as barriers to the passage of nano-sized materials into the organism. These structural and functional barriers are provided by the epithelia serving as an interface...

Université de Fribourg

Amino covalent binding approach on iron oxide nanoparticle surface: toward biological applications

Griffete, Nébéwia ; Clift, Martin J.D. ; Lamouri, Aazdine ; Digigow, Reinaldo G. ; Mihut, Adriana M. ; Fink, Alke ; Rothen-Rutishauser, Barbara ; Dietsch, Hervé

In: Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2012, p. -

We report on the synthesis and the surface modification of different types of magnetic iron oxide particles by developing an original process based on diazonium salts chemistry. Particles were first coated with amino groups and then subjected to polyethylene glycol (PEG) surface modification. They were subsequently characterized by Transmission electron microscopy, infrared spectroscopy,...