Université de Fribourg

Engineered nanomaterials: toward effective safety management in research laboratories

Groso, Amela ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Hofmann, Heinrich ; Meyer, Thierry

In: Journal of Nanobiotechnology, 2016, vol. 14, p. 21

It is still unknown which types of nanomaterials and associated doses represent an actual danger to humans and environment. Meanwhile, there is consensus on applying the precautionary principle to these novel materials until more information is available. To deal with the rapid evolution of research, including the fast turnover of collaborators, a user-friendly and easy-to-apply risk...

Université de Fribourg

Improved dynamic response assessment for intra-articular injected iron oxide nanoparticles

Crowe, L. A. ; Tobalem, F. ; Gramoun, A. ; Delattre, B. M. A. ; Grosdemange, K. ; Salaklang, Jatuporn ; Redjem, A. ; Petri-Fink, Alke ; Hofmann, Heinrich ; Vallée, J.-P.

In: Magnetic Resonance in Medicine, 2012, vol. 68, no. 5, p. 1544–1552

The emerging importance of nanoparticle technology, including iron oxide nanoparticles for monitoring development, progression, and treatment of inflammatory diseases such as arthritis, drives development of imaging techniques. Studies require an imaging protocol that is sensitive and quantifiable for the detection of iron oxide over a wide range of concentrations. Conventional signal loss...

Université de Fribourg

Biomedical nanoparticles modulate specific CD4+ T cell stimulation by inhibition of antigen processing in dendritic cells

Blank, Fabian ; Gerber, Peter ; Rothen-Rutishauser, Barbara ; Sakulkhu, Usawadee ; Salaklang, Jatuporn ; Peyer, Karin De ; Gehr, Peter ; Nicod, Laurent P. ; Hofmann, Heinrich ; Geiser, Thomas ; Petri-Fink, Alke ; Garnier, Christophe Von

In: Nanotoxicology, 2011, p. -

Understanding how nanoparticles may affect immune responses is an essential prerequisite to developing novel clinical applications. To investigate nanoparticle-dependent outcomes on immune responses, dendritic cells (DCs) were treated with model biomedical poly(vinylalcohol)-coated super-paramagnetic iron oxide nanoparticles (PVA-SPIONs). PVA-SPIONs uptake by human monocyte-derived DCs (MDDCs)...