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Université de Fribourg

Outbreak of NDM-1-producing Acinetobacter baumannii in France, January to May 2013

Decousser, J. W. ; Jansen, C. ; Nordmann, Patrice ; Emirian, A . ; Bonnin, R. A. ; Anais, L. ; Merle, J. C. ; Poirel, Laurent

In: Eurosurveillance, 2013, vol. 18, no. 31, p. 20547

We report the first outbreak of carbapenem-resistant NDM-1-producing Acinetobacter baumannii in Europe, in a French intensive-care unit in January to May 2013. The index patient was transferred from Algeria and led to the infection/colonisation of five additional patients. Concurrently, another imported case from Algeria was identified. The seven isolates were genetically indistinguishable,...

Université de Fribourg

Carbapenemase-producing enterobacteriaceae in Europe: a survey among national experts from 39 countries, february 2013

Glasner, C. ; Albiger, B. ; Buist, G. ; Tambić Andrašević, A. ; Canton, R. ; Carmeli, Y. ; Friedrich, A. W. ; Giske, C. G. ; Glupczynski, Y. ; Gniadkowski, M. ; Livermore, D. M. ; Nordmann, Patrice ; Poirel, Laurent ; Rossolini, G. M. ; Seifert, H. ; Vatopoulos, A. ; Walsh, T. ; Woodford, N. ; Donker, T. ; Monnet, D. L. ; Grundmann, H. ; group, the European Survey on Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) working

In: Euro Surveillance, 2013, vol. 18, no. 28, p. 20525

The spread of carbapenemase-producing Enterobacteriaceae (CPE) is a threat to healthcare delivery, although its extent differs substantially from country to country. In February 2013, national experts from 39 European countries were invited to self-assess the current epidemiological situation of CPE in their country. Information about national management of CPE was also reported. The results...

Université de Fribourg

Evaluation of Etest® strips for detection of KPC and metallo-carbapenemases in Enterobacteriaceae

Girlich, Delphine ; Halimi, Diane ; Zambardi, Gilles ; Nordmann, Patrice

In: Diagnostic Microbiology and Infectious Disease, 2013, vol. 77, no. 3, p. 200–201

The performance of Etest KPC and MBL strips (bioMérieux) was evaluated as compared to other phenotypic tests for detecting carbapenemases of the KPC-type and metallo-β-lactamases, respectively, on 133 well-characterized enterobacterial isolates. KPC and meropenem-containing MP/MPI Etest had high sensitivity (>92 %) and specificity (>97 %).

Université de Fribourg

Strategy for a rapid detection of carbapenemase-producing Enterobacteriaceae

Dortet, Laurent ; Bréchard, Ludivine ; Cuzon, Gaëlle ; Poirel, Laurent ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2014, vol. 58, no. 4, p. 2441-2445

A prospective survey was conducted on 862 Enterobacteriaceae with reduced susceptibility to carbapenems. The Carba NP test, UV spectrophotometry and DNA microarray were used for detecting carbapenemase producers, and results compared to PCR and sequencing. The 172 carbapenemase producers were detected using the Carba NP test and UV spectrophotometry whereas DNA microarray failed to detect IMI...

Université de Fribourg

Comparative evaluation of a novel chromogenic medium (chromID OXA-48) for detection of OXA-48 producing Enterobacteriaceae

Girlich, Delphine ; Anglade, Claire ; Zambardi, Gilles ; Nordmann, Patrice

In: Diagnostic Microbiology and Infectious Disease, 2014, vol. 77, no. 4, p. 296–300

Comparative evaluation of the recently developed chromogenic culture medium chromID OXA-48 (bioMérieux) with chromID CARBA (bioMérieux) and SUPERCARBA showed that chromID OXA-48 and SUPERCARBA media have the highest sensitivity for detection of OXA-48 producing Enterobacteriaceae (91% and 93%) comparatively to chromID CARBA (21 %). The chromID OXA-48 has the highest specificity, with 100%, as...

Université de Fribourg

Bloodstream infections caused by Pseudomonas spp.; how to detect carbapenemase producers directly from positive blood cultures ?

Dortet, Laurent ; Boulanger, Anne ; Poirel, Laurent ; Nordmann, Patrice

In: Journal of Clinical Microbiology, 2014, vol. 52, no. 4, p. 1269–1273

The Carba NP test has been evaluated to detect carbapenemase-producing Pseudomonas spp. directly from blood cultures. This rapid and cost-effective test permits an early identification of carbapenemase-producing Pseudomonas spp. directly from blood cultures with excellent sensitivity and specificity. Results may be useful in particular for guiding the first-line therapy and epidemiological...

Université de Fribourg

Rapid detection of carbapenemase-producing Enterobacteriaceae from blood cultures

Dortet, L. ; Bréchard, L. ; Poirel, L. ; Nordmann, Patrice

In: Clinical Microbiology and Infection, 2013, p. -

The biochemical-based Carba NP test has been evaluated to detect carbapenemase-producing Enterobacteriaceae (n = 193) directly from spiked blood cultures. It was able to rapidly detect KPC (n = 50), IMP (n = 27), VIM (n = 37), NDM (n = 33) and OXA-48-like producers (n = 46) with sensitivity and specificity of 97.9% and 100%, respectively. This cost-effective technique may be implemented in any...

Université de Fribourg

High rate of faecal carriage of extended-spectrum β-lactamase and OXA-48 carbapenemase-producing Enterobacteriaceae at a University hospital in Morocco

Girlich, D. ; Bouihat, N. ; Poirel, L. ; Benouda, A. ; Nordmann, Patrice

In: Clinical Microbiology and Infection, 2013, p. -

Carbapenemase-producing Enterobacteriaceae isolates are being increasingly reported, particularly from countries surrounding the Mediterranean area. We aimed to quantify the prevalence of carbapenemase- and extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in rectal swabs from hospitalized patients in a University hospital in Morocco, and to compare the performance of three...