Université de Fribourg

The mgrB gene as a key target for acquired resistance to colistin in Klebsiella pneumoniae

Poirel, Laurent ; Jayol, Aurélie ; Bontron, Séverine ; Villegas, Maria-Virginia ; Ozdamar, Melda ; Türkoglu, Salih ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2014, p. dku323

Objectives Alterations in the PhoPQ two-component regulatory system may be associated with colistin resistance in Klebsiella pneumoniae. MgrB is a small transmembrane protein produced upon activation of the PhoPQ signalling system, and acts as a negative regulator on this system. We investigated the role of the MgrB protein as a source of colistin resistance in a series of K. pneumoniae.Methods...