Université de Fribourg

Cross-resistance to human cationic antimicrobial peptides and to polymyxins mediated by the plasmid-encoded MCR-1?

Dobias, Jan ; Poirel, Laurent ; Nordmann, Patrice

In: Clinical Microbiology and Infection, 2017, p. -

To evaluate whether acquired resistance to cationic antimicrobial peptides (CAMP) group molecules, being normal components of the human immune system, may select co-resistance to antibiotic peptides such as polymyxins, considering they share the same mechanism of action. We aimed to evaluate strains producing the recently identified plasmid-encoded polymyxin resistance determinant MCR-1,...

Université de Fribourg

In vitro activity of ceftazidime, ceftaroline and aztreonam alone and in combination with avibactam against European Gram-negative and Gram-positive clinical isolates

Testa, Raymond ; Cantón, Rafael ; Giani, Tommaso ; Morosini, María-Isabel ; Nichols, Wright W. ; Seifert, Harald ; Stefanik, Danuta ; Rossolini, Gian Maria ; Nordmann, Patrice

In: International Journal of Antimicrobial Agents, 2015, vol. 45, no. 6, p. 641–646

Recent clinical isolates of key Gram-negative and Gram-positive bacteria were collected in 2012 from hospitalised patients in medical centres in four European countries (France, Germany, Italy and Spain) and were tested using standard broth microdilution methodology to assess the impact of 4 mg/L avibactam on the in vitro activities of ceftazidime, ceftaroline and aztreonam. Against...

Université de Fribourg

Carbapenemase-producing Enterobacteriaceae: Overview of a major public health challenge = Entérobactéries et carbapénémases : bilan et enjeux d’un problème de santé publique majeur

Nordmann, Patrice

In: Médecine et Maladies Infectieuses, 2014, vol. 44, no. 2, p. 51–56

Bacterial resistance to antibiotics has become a major source of concern for public health. Enterobacteriaceae are among the most common human pathogens, causing community-acquired as well as hospital-acquired infections. Carbapenem-resistant Enterobacteriaceae have been increasingly reported worldwide since their first identification more than 20 years ago. Three main classes of carbapenemases...