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    Université de Fribourg

    Key features of mcr-1-bearing plasmids from Escherichia coli isolated from humans and food

    Zurfluh, Katrin ; Nüesch-Inderbinen, Magdalena ; Klumpp, Jochen ; Poirel, Laurent ; Nordmann, Patrice ; Stephan, Roger

    In: Antimicrobial Resistance & Infection Control, 2017, vol. 6, p. 91

    Mcr-1-harboring Enterobacteriaceae are reported worldwide since their first discovery in 2015. However, a limited number of studies are available that compared full-length plasmid sequences of human and animal origins.

    Université de Fribourg

    Screening for fecal carriage of MCR-producing Enterobacteriaceae in healthy humans and primary care patients

    Zurfluh, Katrin ; Stephan, Roger ; Widmer, Andreas ; Poirel, Laurent ; Nordmann, Patrice ; Nüesch, Hans-Jakob ; Hächler, Herbert ; Nüesch-Inderbinen, Magdalena

    In: Antimicrobial Resistance & Infection Control, 2017, vol. 6, p. 28

    The objective of this study was to test the efficacy of an inhibitor of the New Delhi metallo-β- lactamase (NDM-1). Inhibiting expression of this type of antibiotic-resistance gene has the potential to restore antibiotic susceptibility in all bacteria carrying the gene.Methods: We have constructed a peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) that selectively inhibits...