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Very low prevalence of MCR-1/MCR-2 plasmid-mediated colistin resistance in urinary tract Enterobacteriaceae in Switzerland

Liassine, Nadia ; Assouvie, Laetititia ; Descombes, Marie-Christine ; Dénervaud Tendon, Valérie ; Kieffer, Nicolas ; Poirel, Laurent ; Nordmann, Patrice

In: International Journal of Infectious Diseases, 2016, vol. 51, p. 4–5

High prevalence of carbapenemase-producing enterobacteriaceae among hospitalized children in luanda, angola

Kieffer, Nicolas ; Nordmann, Patrice ; Aires-de-Sousa, Marta ; Poirel, Laurent

In: Antimicrobial Agents and Chemotherapy, 2016, vol. 60, no. 10, p. 6189–6192

This study aimed to evaluate the prevalence of carbapenemase-producing Enterobacteriaceae in Luanda, Angola. A total of 157 rectal samples were collected from children visiting a pediatric hospital in Luanda in March 2015. Fifty-seven imipenem-nonsusceptible enterobacterial isolates were recovered, most of which were non-clonally related. The blaOXA-181 (50/57) and blaNDM-1 (7/57)...

Features of the mcr-1 cassette related to colistin resistance

Zurfluh, Katrin ; Kieffer, Nicolas ; Poirel, Laurent ; Nordmann, Patrice ; Stephan, Roger

In: Antimicrobial Agents and Chemotherapy, 2016, vol. 60, no. 10, p. 6438–6439

Genetic features of MCR-1-producing colistin-resistant Escherichia coli isolates in South Africa

Poirel, Laurent ; Kieffer, Nicolas ; Brink, Adrian ; Coetze, Jennifer ; Jayol, Aurélie ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2016, vol. 60, no. 7, p. 4394–4397

A series of colistin-resistant Escherichia coli clinical isolates was recovered from hospitalized and community patients in South Africa. Seven clonally unrelated isolates harbored the mcr-1 gene located on different plasmid backbones. Two distinct plasmids were fully sequenced, and identical 2,600-bp-long DNA sequences defining a mcr-1 cassette were identified. Promoter sequences responsible...

Plasmid-mediated carbapenem and colistin resistance in a clinical isolate of Escherichia coli

Poirel, Laurent ; Kieffer, Nicolas ; Liassine, Nadia ; Thanh, Dang ; Nordmann, Patrice

In: The Lancet Infectious Diseases, 2016, vol. 16, no. 3, p. 281

VIM-1, VIM-34, and IMP-8 carbapenemase-producing Escherichia coli strains recovered from a portuguese river

Kieffer, Nicolas ; Poirel, Laurent ; Bessa, Lucinda J. ; Barbosa-Vasconcelos, Ana ; Costa, Paulo Martins da ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2016, vol. 60, no. 4, p. 2585–2586

Plasmid-mediated colistin-resistant Escherichia coli in bacteremia in Switzerland

Nordmann, Patrice ; Lienhard, Reto ; Kieffer, Nicolas ; Clerc, Olivier ; Poirel, Laurent

In: Clinical Infectious Diseases, 2016, vol. 62, no. 10, p. 1322–1323

Co-occurrence of extended spectrum β lactamase and MCR-1 encoding genes on plasmids

Haenni, Marisa ; Poirel, Laurent ; Kieffer, Nicolas ; Châtre, Pierre ; Saras, Estelle ; Métayer, Véronique ; Dumoulin, Romain ; Nordmann, Patrice ; Madec, Jean-Yves

In: The Lancet Infectious Diseases, 2016, vol. 16, no. 3, p. 281–282

In vitro evaluation of dual carbapenem combinations against carbapenemase-producing Enterobacteriaceae

Poirel, Laurent ; Kieffer, Nicolas ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2016, vol. 71, no. 1, p. 156–161

Objectives: This study aimed to analyse the in vitro activity of dual combinations of carbapenems against Klebsiella pneumoniae producing the main carbapenemase types.Methods: MIC values of the carbapenems, imipenem, meropenem, ertapenem and doripenem were determined alone and in dual combinations for 20 clinical K. pneumoniae isolates producing representative carbapenemases, i.e. OXA-48...

Emergence of colistin resistance in Klebsiella pneumoniae from veterinary medicine

Kieffer, Nicolas ; Poirel, Laurent ; Nordmann, Patrice ; Madec, Jean-Yves ; Haenni, Marisa

In: Journal of Antimicrobial Chemotherapy, 2015, vol. 70, no. 4, p. 1265-1267