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Characterization of BRPMBL the bleomycin resistance protein associated with the carbapenemase NDM

Dortet, Laurent ; Girlich, Delphine ; Virlouvet, Anne-Laure ; Poirel, Laurent ; Nordmann, Patrice ; Iorga, Bogdan I. ; Naas, Thierry

In: Antimicrobial Agents and Chemotherapy, 2017, vol. 61, no. 3, p. e02413-16

The metallo-β-lactamase NDM-1 is among the most worrisome resistance determinants and is spreading worldwide among Gram-negative bacilli. A bleomycin resistance gene, bleMBL, downstream of the blaNDM-1 gene has been associated with resistance almost systematically. Here, we characterized the corresponding protein, BRPMBL, conferring resistance to bleomycin,...