Université de Fribourg

Complete genome sequencing of Acinetobacter baumannii str. K50 disclosed the large conjugative plasmid pK50a encoding the carbapenemase OXA-23 and the extended-spectrum β–lactamase GES-11

Wibberg, Daniel ; Salto, Ileana P. ; Eikmeyer, Felix G. ; Maus, Irena ; Winkler, Anika ; Nordmann, Patrice ; Pühler, Alfred ; Poirel, Laurent ; Schlüter, Andreas

In: Antimicrobial Agents and Chemotherapy, 2018, p. AAC.00212-18

Multidrug-resistant (MDR) Acinetobacter baumannii strains appeared as serious emerging nosocomial pathogens in clinical environments and especially in intensive care units (ICUs). A. baumannii strain K50 recovered from a hospitalized patient in Kuwait exhibited resistance to carbapenems, and additionally to ciprofloxacin, chloramphenicol, sulfonamides, amikacin and gentamicin. Genome...

Université de Fribourg

Intraspecies transfer of the chromosomal Acinetobacter baumannii blaNDM-1 carbapenemase gene

Krahn, Thomas ; Wibberg, Daniel ; Maus, Irena ; Winkler, Anika ; Bontron, Séverine ; Sczyrba, Alexander ; Nordmann, Patrice ; Pühler, Alfred ; Poirel, Laurent ; Schlüter, Andreas

In: Antimicrobial Agents and Chemotherapy, 2016, vol. 60, no. 5, p. 3032–3040

The species Acinetobacter baumannii is one of the most important multidrug-resistant human pathogens. To determine its virulence and antibiotic resistance determinants, the genome of the nosocomial blaNDM-1-positive A. baumannii strain R2090 originating from Egypt was completely sequenced. Genome analysis revealed that strain R2090 is highly related to the...

Université de Fribourg

Complete genome sequence of the clinical strain Acinetobacter baumannii R2090 Carrying the chromosomally encoded Metallo-β-Lactamase Gene blaNDM-1

Krahn, Thomas ; Wibberg, Daniel ; Maus, Irena ; Winkler, Anika ; Nordmann, Patrice ; Pühler, Alfred ; Poirel, Laurent ; Schlüter, Andreas

In: Genome Announcements, 2016, vol. 3, no. 5, p. e01008-15

Acinetobacter baumannii is an emerging human pathogen causing nosocomial and community-acquired infections. Here, we present the complete genome sequence of the clinical A. baumannii strain R2090 carrying the metallo-β-lactamase gene blaNDM-1 in its chromosome within the transposon Tn125.

Université de Fribourg

IncH-type plasmid harboring the blaCTX-M-15, blaDHA-1, and qnrB4 genes recovered from animal isolates

Schlüter, Andreas ; Nordmann, Patrice ; Bonnin, Rémy A. ; Millemann, Yves ; Eikmeyer, Felix G. ; Wibberg, Daniel ; Pühler, Alfred ; Poirel, Laurent

In: Antimicrobial Agents and Chemotherapy, 2014, p. AAC.02695–14

The whole sequence of plasmid pENVA carrying the extended-spectrum ß-lactamase gene blaCTX-M-15 was determined. It has been identified from a series of clonally-related Klebsiella pneumoniae ST274 strains recovered from companion animals. This plasmid was 253,984-bp in-size and harbored, in addition to blaCTX-M-15, a large array of genes encoding...