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Université de Fribourg

Uninephrectomy-induced lipolysis and low-grade inflammation are mimicked by unilateral renal denervation

Arsenijevic, Denis ; Cajot, Jean-François ; Fellay, Benoit ; Dulloo, Abdul G. ; Vliet, Bruce N. Van ; Montani, Jean-Pierre

In: Integrative Physiology, 2016, p. 227

Uninephrectomy (UniNX) in rats on a fixed food intake leads to increased lipolysis and a low-grade inflammation with an increased subset of circulating cytokines. Because UniNX ablates renal nerves on the side of the removed kidney, we tested the contribution of unilateral renal denervation in the phenotype of UniNX. We compared Sham-operated controls, left nephrectomy (UniNX) and unilateral...

Université de Fribourg

Uninephrectomy in rats on a fixed food intake potentiates both anorexia and circulating cytokine subsets in response to LPS

Arsenijevic, Denis ; Montani, Jean-Pierre

In: Frontiers in Immunology - Inflammation, 2015, p. 641

Recent human studies have suggested that mild reduction in kidney function can alter immune response and increase susceptibility to infection. The role of mild reduction in kidney function in altering susceptibility to bacterial lipopolysaccharide (LPS) responses was investigated in uninephrectomized rats compared to Sham-operated controls rats 4 weeks after surgery. Throughout the 4 weeks, all...

Université de Fribourg

Hemodynamic consequences of chronic parasympathetic blockade with a peripheral muscarinic antagonist

Ayer, Antoine ; Antic, Vladan ; Dulloo, Abdul G. ; Vliet, Bruce N. van ; Montani, Jean-Pierre

In: American Journal of Physiology: Heart and Circulatory Physiology, 2007, vol. 293, p. H1265-H1272

hereas the sympathetic nervous system has a well-established role in blood pressure (BP) regulation, it is not clear whether long-term levels of BP are affected by parasympathetic function or dysfunction. We tested the hypothesis that chronic blockade of the parasympathetic nervous system has sustained effects on BP, heart rate (HR), and BP variability (BPV). Sprague-Dawley rats were...

Université de Fribourg

Mature adipocytes and perivascular adipose tissue stimulate vascular smooth muscle cell proliferation: effects of aging and obesity

Barandier, Christine ; Montani, Jean-Pierre ; Yang, Zhihong

In: American Journal of Physiology - Heart & Circulatory Physiology, 2005, vol. 289, p. H1807-H1813

Adipocytes and perivascular adipose tissue are emerging as regulators of vascular function. The effects of adipocytes and perivascular adipose tissue on human smooth muscle cell (SMC) proliferation were investigated. Conditioned medium was prepared from cultured premature and differentiated 3T3-L1 adipocytes and from periaortic adipose tissue from young (3 mo) and old (24 mo) Wistar-Kyoto (WKY)...

Université de Fribourg

PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance

Becattini, Barbara ; Marone, Romina ; Zani, Fabio ; Arsenijevic, Denis ; Seydoux, Josiane ; Montani, Jean-Pierre ; Dulloo, Abdul G. ; Thorens, Bernard ; Preitner, Frédéric ; Wymann, Matthias P. ; Solinas, Giovanni

In: Proceedings of the National Academy of Sciences of the United States of America, 2011, vol. 108, no. 42, p. E854-E863

Obesity is associated with a chronic low-grade inflammation, and specific antiinflammatory interventions may be beneficial for the treatment of type 2 diabetes and other obesity-related diseases. The lipid kinase PI3Kγ is a central proinflammatory signal transducer that plays a major role in leukocyte chemotaxis, mast cell degranulation, and endothelial cell activation. It was also reported that...

Université de Fribourg

Water-induced thermogenesis reconsidered: the effects of osmolality and water temperature on energy expenditure after drinking

Brown, Clive M. ; Dulloo, Abdul G. ; Montani, Jean-Pierre

In: Journal of Clinical Endocrinology and Metabolism, 2006, vol. 91, no. 9, p. 3598-3602

Context: A recent study reported that drinking 500 ml of water causes a 30% increase in metabolic rate. If verified, this previously unrecognized thermogenic property of water would have important implications for weight-loss programs. However, the concept of a thermogenic effect of water is controversial because other studies have found that water drinking does not increase energy...