Université de Fribourg

Thrifty metabolism that favors fat storage after caloric restriction: a role for skeletal muscle phosphatidylinositol-3-kinase activity and AMP-activated protein kinase

Summermatter, Serge ; Mainieri, Davide ; Russell, A. P. ; Seydoux, Josiane ; Montani, Jean-Pierre ; Buchala, Anthony J. ; Solinas, Giovanni ; Dulloo, Abdul G.

In: Faseb Journal, 2008, vol. 22, p. 774-785

Energy conservation directed at accelerating body fat recovery (or catch-up fat) contributes to obesity relapse after slimming and to excess fat gain during catch-up growth after malnutrition. To investigate the mechanisms underlying such thrifty metabolism for catch-up fat, we tested whether during refeeding after caloric restriction rats exhibiting catch-up fat driven by suppressed...

Université de Fribourg

The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation

Solinas, Giovanni ; Summermatter, Serge ; Mainieri, Davide ; Gubler, Marcel ; Pirola, Luciano ; Wymann, Matthias P. ; Rusconi, Sandro ; Montani, Jean-Pierre ; Seydoux, Josiane

In: FEBS Letters, 2004, vol. 577, no. 3, p. 539-544

We report here studies that integrate data of respiration rate from mouse skeletal muscle in response to leptin and pharmacological interference with intermediary metabolism, together with assays for phosphatidylinositol 3-kinase (PI3K) and AMP- activated protein kinase (AMPK). Our results suggest that the direct effect of leptin in stimulating thermogenesis in skeletal muscle is mediated by...