Université de Fribourg

Hemodynamic consequences of chronic parasympathetic blockade with a peripheral muscarinic antagonist

Ayer, Antoine ; Antic, Vladan ; Dulloo, Abdul G. ; Vliet, Bruce N. van ; Montani, Jean-Pierre

In: American Journal of Physiology: Heart and Circulatory Physiology, 2007, vol. 293, p. H1265-H1272

hereas the sympathetic nervous system has a well-established role in blood pressure (BP) regulation, it is not clear whether long-term levels of BP are affected by parasympathetic function or dysfunction. We tested the hypothesis that chronic blockade of the parasympathetic nervous system has sustained effects on BP, heart rate (HR), and BP variability (BPV). Sprague-Dawley rats were...

Université de Fribourg

Increased salt-sensitivity in endothelial nitric oxide synthase–knockout mice

Leonard, Allison M. ; Chafe, Linda L. ; Montani, Jean-Pierre ; Vliet, Bruce N. Van

In: American Journal of Hypertension, 2006, vol. 19, no. 12, p. 1264-1269

Background Although impaired nitric oxide production contributes importantly to salt-sensitivity, the role of the endothelial isoform of nitric oxide synthase (eNOS) has received little attention. In the present study we compared the effects of a high-salt diet on the blood pressure response of eNOS knockout (eNOS−/−) and control (eNOS+/+) mice. Methods Mean arterial pressure (MAP), heart...