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Hemodynamic consequences of chronic parasympathetic blockade with a peripheral muscarinic antagonist

Ayer, Antoine ; Antic, Vladan ; Dulloo, Abdul G. ; Vliet, Bruce N. Van ; Montani, Jean-Pierre

In: American Journal of Physiology: Heart and Circulatory Physiology, 2007, vol. 293, p. H1265-H1272

hereas the sympathetic nervous system has a well-established role in blood pressure (BP) regulation, it is not clear whether long-term levels of BP are affected by parasympathetic function or dysfunction. We tested the hypothesis that chronic blockade of the parasympathetic nervous system has sustained effects on BP, heart rate (HR), and BP variability (BPV). Sprague-Dawley rats were...